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p53 Information
p53 monoclonal antibodies
mouse models
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Monkey p53
All but two monoclonal antibodies which react with human p53, cross react with monky p53 due to the high homology between the primates p53
The 2 exceptions are : HO7.1 and HO33.8
| Human p53 sequence |
291 |
K |
K |
G |
E |
P |
H |
H |
E |
L |
P |
300 |
| Monkey p53 sequence |
291 |
K |
K |
G |
E |
C |
H |
H |
E |
L |
P |
300 |
Epitope recognized by HO7.1 and HO33.8
It has been demonstrated experimentally that HO7.1 does not recognize monkey p53 either by immunoprecipitation or western blot.
Reference
- 13 Legros Y, Meyer A, Ory K and Soussi T (1994) Mutations in p53 produce a common conformational effect that can be detected with a panel of monoclonal antibodies directed toward the central part of the p53 protein. Oncogene 9 : 3689-3694.
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