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p53 Information
p53 information
p53 story
p53 monoclonal antibodies
p53 pathways
p53 gene
mdm family
mouse models
ASPP family
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Mouse models
The first transgenic mouse for p53 was published in 1989 by Lavigeur et al. This mouse overexpress a mutant p53 transgene (A135V). This mouse is prone to various types of cancer. Recently, it has been shown that this mouse displays early ageing-associated phenotypes.
Later, the first p53 deficient mice was produced by two different groups (see below).
Mouse model related to p53 can be arbitrarily divided in 7 categories
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| Category 1: knockout model (p53 KO) where the endogenous p53 gene is either totally or partially deleted either in whole body or in specific tissue. New models with specific deletion of various p53 isoforms could be included in this category. |
| Category 2: mouse model overexpressing various types of p53 transgene (wt or mutant, mouse-human hybrids) |
| Category 3: any cross between a p53 KO and any other mouse models with either activated oncogene, deleted tumor suppressor genes or both. The number of this type of mouse models is high and increase in complexity every year. |
| Category 4: any knockin model (p53 KI) where wt p53 is transformed into a mutant p53 found in human cancer |
| Category 5: any knockin model (p53 KI) where wt p53 is transformed into a mutant corresponding to a residue or a region of p53 important for its function (phosphorylation sites) |
| Category 6: knockout model for genes important for the p53 pathway, either upstream such as ATM, downstream such as p21 or bax or regulating p53 activity such as mdm2. |
| Category 7: knockout model for other members of the p53 family (p73 and p63) and intercross between them or with p53 KO |
Only category 1, 2, 4, 5 and 7 will be described here. If you have any documents concerning the other categories and are willing to share them with the sciientific community, let me know.
More information on p53 function during murine development can be found at this page
| Genotype* |
Property |
Phenoype of the mouse** |
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p53 gene deletion |
Tumor prone |
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exon 1 to 6 deletion |
Aging phenotype |
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thermosensitive murine p53 mutant |
Tumor prone ; aging phenotype |
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3 copies of the p53 gene |
No obvious phenotype, more resistant to cancer |
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mouse/human p53 hybrid |
No obvious phenotype |
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human p53 transgene in a p53 null background |
Tumor prone; apoptosis defect |
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wt for growth arrest
impaired for apoptosis |
Tumor prone (late onset): tumor spectrum different from p53 KO |
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hot spot mutation in human cancer |
Tumor prone; tumor spectrum different from p53 KO |
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hot spot mutation in human cancer |
Tumor prone: tumor spectrum different from p53 KO |
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Phosphorylation site |
No obvious phenotype |
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Phosphorylation site |
No obvious phenotype |
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Phosphorylation site |
No obvious phenotype |
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Ubiquitination site (7 Lysine in the carboxy-terminus) |
No obvious phenotype |
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deletion of the proline rich region |
Slight tumor susceptibility |
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negative regulator of p53 |
embryonic lethality rescued by p53-/- |
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reduced expression of mdm2 |
anemia, increased radiosensitivity rescued in a p53 null background |
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negative regulator of p53 |
embryonic lethality rescued by p53-/- |
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p53 family |
viable; various defects including tumor development |
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p53 family |
many in utero death; very short viability; development defect; lack of epithelium formation |
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short viability, prone to cancer |
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p53 family |
high frequency of metastatic tumors |
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p53 family |
high frequency of metastatic tumors |
** except for p63/p73, p63/p53 and p73/p53 animals, only the phenotype of the homozygote mice is described. More information are available on each specific page.
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