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p53 Information
mouse models
|
Rabbit p53
Monoclonal antibodies developped toward other p53 but that cross react with Rabbit p53
| Name |
Epitope Location |
Antigen used for immunization |
Isotype |
Other species recognition |
WB |
IP |
Reference
|
Comercial availability |
| B17 |
16-25 |
Human p53 |
IgG2a |
Yes |
Yes |
Yes |
11, 12, 23 |
No |
| C36 |
16-30 |
Human p53 |
IgG1 |
Yes |
Yes |
Yes |
11, 12, 23
|
No |
| HP64 |
171-185 |
Human p53 |
IgG1 |
Yes |
Yes |
Yes |
11, 12, 23
|
No |
| PAb240
|
213-217
|
Murine p53
|
IgG1
|
Yes
|
Yes
|
Yes
|
11, 12, 23
|
Yes
|
| HR231 |
371-380 |
Human p53 |
IgG2b |
Yes |
Yes |
Yes |
11, 12, 23
|
No |
| PAb122
|
371-380
|
Murine p53
|
IgG2b
|
Yes
|
Yes
|
Yes
|
11, 12, 23
|
Yes
|
| Pab 421
|
371 -380
|
Murine p53
|
IgG2a
|
Yes
|
Yes
|
Yes
|
11, 12, 23
|
Yes
|
Only mAbs that have been experimentally tested either by ELISA, immunoprecipitation or western blot are listed on these tables.
From the epitope sequence, it is quite possible that other mAbs react with this species.
References
- 11 Legros Y, Lacabanne V, D'Agay MF, Larsen CJ, Pla M and Soussi T (1993) Production of human p53 specific monoclonal antibodies and their use in immunohistochemical studies of tumor cells. Bull. du Cancer 80 : 102-110.
- 12 Legros Y, Lafon C and Soussi T (1994) Linear antigenic sites defined by the B-cell response to human p53 are localized predominantly in the amino and carboxy-termini of the protein. Oncogene 9 : 2071-2076.
- 23 Le Goas, F., May, P., Ronco, P., and Caron de Fromentel, (1997) cDNA cloning and immunological characterization of rabbit p53. Gene, 185, 169-173
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