p53 Information

p53 information

p53 story

p53 monoclonal antibodies

p53 pathways

p53 gene

p53 protein(s)

modifications of p53

p53 isoforms

p53 domains

p53 partners






mdm family

p63/p73 protein(s)

p53 evolution

p53 polymorphism

p53 and cancer

mouse models

ASPP family


Post translational modifications of p53

A variety of genotoxic and non genotoxic stresses lead to stabilization and activation of p53 that are mediated by multiple post-translational modifications. The N-terminus of p53 is heavily phosphorylated, whereas the C-terminus may be phosphorylated, acetylated neddylated, ubiquitinated or sumoylated.


Modifications at the amino-terminus of the p53 protein after DNA damage


Multiple modifications of the carboxy-terminus of p53 the protein


Modifications of the DNA binding domain of the p53 protein



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