p53 Information

p53 information

p53 story

p53 monoclonal antibodies

p53 pathways

p53 gene

p53 protein(s)

mdm family

p63/p73 protein(s)

p53 evolution

p53 polymorphism

p53 and cancer

mouse models

p53 Alignment

Alignment of fish p53 proteins unsing ClustalW: only full-length proteins have been used.
A pdf document with this alignment is available -> pdf

p53_Tetraodon_miurus        -MEEENIS----LPLSQDTFQDLWDN----VSAPPISTIQTAALENEAWP 41

p53_Platichthys_flesus      -MDEQGLDGMQILPGSQDSFSELWAS----VQTPSIATI----------- 34

p53_Xiph_maculatus          -MEEADLT----LPLSQDTFHDLWNN----VFLSTENES----------- 30

p53_Xiph_hellerii           -MEEADLT----LPLSQDTFHDLWNN----VFLSTENES----------- 30

p53_Danio_rerio             ----------MAQN-DSQEFAELWEK--NLIIQPPGGGSCWDIINDE--- 34

p53_Barbus                  ----------MAE---SQEFAELWER--NLISTQEAG-TCWELIND---- 30

p53_Ictalurus               MEGNGERDTMMVEPPDSQEFAELWLR--NLIVR---DNSLWGKEEE---- 41

p53_rainbow_trout           ---MADLAENVSLPLSQESFEDLWKMNLNLVAVQPPETESWVGYDNFMME 47

p53_Tetraodon_miurus        AERQMNMMCNFMDSTFNEALFNLLPEPPSRDGANSSSPTVPVTTDYPGEY 91

p53_Platichthys_flesus      AEEFDDHLGNLLQNGFDMNLFELPPEMVAKDSVTPPSSTVPVVTDYPGEY 84

p53_Xiph_maculatus          LPPPEGLLSQNMD-------FWEDPETMQETKNVPTAPTVPAISNYAGEH 73

p53_Xiph_hellerii           LAPPEGLLSQNMD-------FWEDPETMQETKNVPTAPTVPAISNYAGEH 73

p53_Danio_rerio             EYLPGSFDPNFFENVLEE---QPQPST------LPPTSTVPETSDYPGDH 75

p53_Barbus                  EYLPSSFDPNIFDNVLTE---QPQPST------SPPTASVPVATDYPGEH 71

p53_Ictalurus               --IPDDLQEVPCDVLLSDM-LQPQSSS------SPPTSTVPVTSDYPGLL 82

p53_rainbow_trout           APLQVEFDPSLFEVSATEP--APQPSISTLDTGSPPTSTVPTTSDYPGAL 95

p53_Tetraodon_miurus        GFKLRFQKSGTAKSVTSTYSEILNKLYCQLAKTSLVEVLLGKDPPMGAVL 141

p53_Platichthys_flesus      GFQLRFQKSGTAKSVTSTFSELLKKLYCQLAKTSPVEVLLSKEPPQGAVL 134

p53_Xiph_maculatus          GFNLEFNDSGTAKSVTSTYSVKLGKLFCQLAKTTPIGVLVKEEPPQGAVI 123

p53_Xiph_hellerii           GFNLEFNDSGTAKSVTSTYSVKLGKLFCQLAKTTPIGVLVKEEPPQGAVI 123

p53_Danio_rerio             GFRLRFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQGSVV 125

p53_Barbus                  GFKLGFPQSGTAKSVTCTYSSDLNKLFCQLAKTCPVQMVVNVAPPQGSVI 121

p53_Ictalurus               NFTLHFQESSGTKSVTCTYSPDLNKLFCQLAKTCPVLMAVSSSPPPGSVL 132

p53_rainbow_trout           GFQLRFLQSSTAKSVTCTYSPDLNKLFCQLAKTCPVQIVVDHPPPPGAVV 145

p53_Tetraodon_miurus        RATAIYKKTEHVAEVVRRCPHHQN----EDSAEHRSHLIRMEGSERAQYF 187

p53_Platichthys_flesus      RATAVYKKTEHVADVVRRCPHHQT----EDTAEHRSHLIRLEGSQRALYF 180

p53_Xiph_maculatus          RATAVYKKTEHVGEVVKRCPHHQS----EDLSDNKSHLIRVEGSQLAQYF 169

p53_Xiph_hellerii           RATSVYKKTEHVGEVVKRCPHHQS----EDLSDNKSHLIRVEGSQLAQYF 169

p53_Danio_rerio             RATAIYKKSEHVAEVVRRCPHHERTPDG-DNLAPAGHLIRVEGNQRANYR 174

p53_Barbus                  RATAIYKKSEHVAEVVRRCPHHERTPDG-DGLAPAAHLIRVEGNSRALYR 170

p53_Ictalurus               RATAVYKRSEHVAEVVRRCPHHERSNDSSDGPAPPGHLLRVEGNSRAVYQ 182

p53_rainbow_trout           RALAIYKKLSDVADVVRRCPHHQSTSENNEGPAPRGHLVRVEGNQRSEYM 195

p53_Tetraodon_miurus        EHPHTKRQSVTVPYEPPQLGSEFTTILLSFMCNSSCMGGMNRRPILTILT 237

p53_Platichthys_flesus      EDPHTKRQSVTVPYEPPQLGSETTAILLSFMCNSSCMGGMNRRQILTILT 230

p53_Xiph_maculatus          EDPNTRRHSVTVPYERPQLGSEMTTILLSFMCNSSCMGGMNRRPILTILT 219

p53_Xiph_hellerii           EDPNTRRHSVTVPYERPQLGSEMTTILLSFMCNSSCMGGMNRRPILTILT 219

p53_Danio_rerio             EDNITLRHSVFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIIT 224

p53_Barbus                  EDDVNSRHSVVVPYEVPQLGSEFTTVLYNFMCNSSCMGGMNRRPILTIIS 220

p53_Ictalurus               EDGNTQAHSVVVPYEPPQVGSQSTTVLYNYMCNSSCMGGMNRRPILTIIT 232

p53_rainbow_trout           EDGNTLRHSVLVPYEPPQVGSECTTVLYNFMCNSSCMGGMNRRPILTIIT 245

p53_Tetraodon_miurus        LETQEGIVLGRRCFEVRVCACPGRDRKTEETNS-------TKMQNDAKDA 280

p53_Platichthys_flesus      LETPDGLVLGRRCFEVRVCACPGRDRKTDEESS-------TKTPNGPKQT 273

p53_Xiph_maculatus          LETTEGEVLGRRCFEVRVCACPGRDRKTEEGNL-------EKS--GTKQT 260

p53_Xiph_hellerii           LETTEGEVLGRRCFEVRVCACPGRDRKTEEGNL-------EKS--GTKQT 260

p53_Danio_rerio             LETQEGQLLGRRSFEVRVCACPGRDRKTEESNFKKDQET--KTMAKTTTG 272

p53_Barbus                  LETHDGQLLGRRSFEVRVCACPGRDRKTEESNFRKDQET--KTLDKIPSA 268

p53_Ictalurus               LETQDGHLLGRRTFEVRVCACPGRDRKTEESNFKKQQEP--KTSGKTLT- 279

p53_rainbow_trout           LETQEGQLLGRRSFEVRVCACPGRDRKTEEINLKKQQETTLETKTKPAQG 295

p53_Tetraodon_miurus        KKRKSVPT---PDSTTIKKSKTASSAEEDNNEVYTLQIRGRKRYEMLKKI 327

p53_Platichthys_flesus      KKRKQAPSNSAPHTTTVMKSKSSSSAEEEDKEVFTVLVKGRERYEIIKKI 323

p53_Xiph_maculatus          KKRKSAPA---PDTSTAKKSKSASSGEDEDKEIYTLSIRGRNRYLWFKSL 307

p53_Xiph_hellerii           KKRKSAPA---PDTSTAKKSKSASSGEDEDKEIYTLSIRGRNRYLWFKSL 307

p53_Danio_rerio             TKRSLVKESSSATLRPEGSKKAKGS--SSDEEIFTLQVRGRERYEILKKL 320

p53_Barbus                  NKRSLTKDSTSSVPRPEGSKKAKLSG-SSDEEIYTLQVRGKERYEMLKKI 317

p53_Ictalurus               -KRSMKDPPS----HPEASKKSKNS--SSDDEIYTLQVRGKERYEFLKKI 322

p53_rainbow_trout           IKRAMK-EASLPAPQPGASKKTKSSPAVSDDEIYTLQIRGKEKYEMLKKF 344

p53_Tetraodon_miurus        NDGLD-------LLENKPKSKATHR-------PDGPIPPSGKRLLHRGE- 362

p53_Platichthys_flesus      NEAFEG-----AAEKEKAKNKVAVK-------QELPVPSSGKRLVQRGE- 360

p53_Xiph_maculatus          NDGLE----------LMDKTGPKIK-------QEIPAPSSGKRLLKGG-- 338

p53_Xiph_hellerii           NDGLE----------LMDKTGPKIK-------QEIPAPSSGKRLLKGG-- 338

p53_Danio_rerio             NDSLELSDVVPASDAEKYRQKFMTK--NKKENRESSEPKQGKKLMVKDEG 368

p53_Barbus                  NDSLELSDVVPPSEMDRYRQKLLTK--GKKKDGQTPEPKRGKKLMVKDE- 364

p53_Ictalurus               NDGLELSDVVPPADQEKYRQKLLSKTCRKERDGAAGEPKRGKKRLVKEE- 371

p53_rainbow_trout           NDSLELSELVPVADADKYRQKCLTKRVAKRDFGVG--PKKRKKLLVKEE- 391

p53_Tetraodon_miurus        KSDSD 367

p53_Platichthys_flesus      RSDSD 365

p53_Xiph_maculatus          -SDSD 342

p53_Xiph_hellerii           -SDSD 342

p53_Danio_rerio             RSDSD 373

p53_Barbus                  KSDSD 369

p53_Ictalurus               KCDSD 376

p53_rainbow_trout           KSDSD 396