p53 Information

p53 information

p53 story

p53 monoclonal antibodies

p53 pathways

p53 gene

p53 protein(s)

mdm family

p63/p73 protein(s)

p53 evolution

p53 polymorphism

p53 and cancer

mouse models

p53 Alignment

Alignment of all p53 proteins unsing ClustalW: only full-length proteins have been used.
A pdf document with this alignment is available -> pdf

p53_Homo_Sapiens            -MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPS----QAMDDLML 45

p53_Afr_Green_Monk.         -MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSPLPS----QAVDDLML 45

p53_Mac_Fascicularis        -MEEPQSDPSIEPPLSQETFSDLWKLLPENHVLSPLPS----QAVDDLML 45

p53_Mac_Fuscata             -MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSPLPS----QAVDDLML 45

p53_Mac__Mulatta            -MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSPLPS----QAVDDLML 45

p53_Guinea_pig              -MEEPHSDLSIEPPLSQETFSDLWKLLPENNVLSDSLS----PPMDHLLL 45

p53_Bugs_Bunny              -MEESQSDLSLEPPLSQETFSDLWKLLPENNLLTTSLN----PPVDD-LL 44

p53_Gold_hamster            -MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLSTLP--SS-DSIEELFL 46

p53_Chinese_hamster         -MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLSTLP--SS-DSIEELFL 46

p53_Gerbil                  -MEEPQSDLSIEPPLSQETFSDLWKLLPPKNLLS-----AL-EPMEDLLL 43

p53_Rat                     -MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATGSP-NSMEDLFL 48

p53_Marmota_monax           -MEEAQSDLSIEPPLSQETFSDLWNLLPENNVLSPVLS----PPMDDLLL 45

p53_Spalax                  -MEEQQSDLSIEPPLSQETFSDLWKLLPQNNVLSTPL--SP-NSMEDLLL 46

p53_Tree_shrew              -MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPS----QAMDDLML 45

p53_Mus_musculus            -MEESQSDISLELPLSQETFSGLWKLLPPEDILP-----SP-HCMDDLLL 43

p53_Bos_indicus             -MEESQAELNVEPPLSQETFSDLWNLLPENNLLSSELS----APVDDLLP 45

p53_Bos_taurus              -MEESQAELNVEPPLSQETFSDLWNLLPENNLLSSELS----APVDDLLP 45

p53_Sheep                   -MEESQAELGVEPPLSQETFSDLWNLLPENNLLSSELS----APVDDLLP 45

p53_Pig                     -MEESQSELGVEPPLSQETFSDLWKLLPENNLLSSELS---LAAVNDLLL 46

p53_Canis_fam               -MEESQSELNIDPPLSQETFSELWNLLPENNVLSSELC----PAVDELLL 45

p53_Beluga_Whale            -MEESQAELGVEPPLSQETFSDLWKLLPENNLLSSELS----PAVDDLLL 45

p53_Felix_Catus             -MQEPPLELTIEPPLSQETFSELWNLLPENNVLSSELS----SAMNELPL 45

p53_Galus                   -MAEEMEPL-LEP---TEVFMDLWSMLP--------------YSMQQLPL 31

p53_X_Tropicalis            --MEPSSETGMEPPLSQETFEDLWSLLP--------------DPLQTGTG 34

p53_X_laevis                --MEPSSETGMDPPLSQETFEDLWSLLP--------------DPLQTVTC 34

p53_Danio_rerio             ----------MAQN-DSQEFAELWEK---NLIIQPPGGGSCWDIINDE-- 34

p53_Barbus                  ----------MAE---SQEFAELWER---NLISTQEAG-TCWELIND--- 30

p53_Xiph_maculatus          -MEEADLT----LPLSQDTFHDLWNN-----VFLSTENESLP-------- 32

p53_Xiph_hellerii           -MEEADLT----LPLSQDTFHDLWNN-----VFLSTENESLA-------- 32

p53_Tetraodon_miurus        -MEEENIS----LPLSQDTFQDLWDN-----VSAPPISTIQTAALENEAW 40

p53_Platichthys_flesus      -MDEQGLDGMQILPGSQDSFSELWAS-----VQTPSIATI---------- 34

p53_Ictalurus               MEGNGERDTMMVEPPDSQEFAELWLR---NLIVR---DNSLWGKEEE--- 41

p53_rainbow_trout           ---MADLAENVSLPLSQESFEDLWKMNL-NLVAVQPPETESWVGYDNFMM 46

p53_Homo_Sapiens            SPDDIEQWFTED-PGPDEAPRMPE------AAPRVAPAPAAPTPAAPAPA 88

p53_Afr_Green_Monk.         SPDDLAQWLTED-PGPDEAPRMSE------AAPHMAPTPAAPTPAAPAPA 88

p53_Mac_Fascicularis        SPDDLAQWLTED-PGPDEAPRMSE------AAPPMAPTPAAPTPAAPAPA 88

p53_Mac_Fuscata             SPDDLAQWLTED-PGPDEAPRMSE------AAPPMAPTPAAPTPAAPAPA 88

p53_Mac__Mulatta            SPDDLAQWLTED-PGPDEAPRMSE------AAPPMAPTPAAPTPAAPAPA 88

p53_Guinea_pig              SPEEVASWLGE---NPDGDGHVSA------APVSEAPTSAGPALVAPAPA 86

p53_Bugs_Bunny              SAEDVANWLNE---DPEEGLRVPA------APAPEAPAPAAPALAAPAPA 85

p53_Gold_hamster            S-ENVAGWLED----PGEALQGSAAAAAPAAPAAEDPVAETPAPVASAPA 91

p53_Chinese_hamster         S-ENVTGWLED----SGGALQG---VAAAAASTAEDPVTETPAPVASAPA 88

p53_Gerbil                  P-QDVTSWLGD----ADEALPVCT------APAEG-PAPEAPAPAAPAPP 81

p53_Rat                     P-QDVAELLEG----PEEALQVS-------APAAQEPGTEAPAPVAPASA 86

p53_Marmota_monax           SSEDVENWFDK---GPDEALQMSA------APAPKAPTPAASTLAAPSPA 86

p53_Spalax                  SPEDVANWLDD----PDEALQV------PAAAITGDPVTETSAPVAPPPA 86

p53_Tree_shrew              SPDDIEQWFTED-PGPDEAPRMPE------AAPPVAPAPAAPTPAAPAPA 88

p53_Mus_musculus            P-QDVEEFFEG----PSEALRVSG------APAAQDPVTETPGPVAPAPA 82

p53_Bos_indicus             Y-TDVATWLDE---CPNEAPQMPE------PSA-----PAAPPPATPAPA 80

p53_Bos_taurus              Y-TDVATWLDE---CPNEAPQMPE------PSA-----PAAPPPATPAPA 80

p53_Sheep                   YSEDVVTWLDE---CPNEAPQMPE------P----------PAQAALAPA 76

p53_Pig                     SP--VTNWLDE---NPDDASRVPA------PPA-----ATAPAPAAPAPA 80

p53_Canis_fam               P-ESVVNWLDE---DSDDAPRMPA------TSA-----PTAPGPAP---- 76

p53_Beluga_Whale            SPEDVANWLDE---RPDEAPQMPE------PPA-----PAAPTPAAPAPA 81

p53_Felix_Catus             S-EDVANWLDE---APDDASGMSA------VPA-----PAAPAPATPAPA 80

p53_Galus                   P-EDHSNWQELSPLEPSDPPPPP-------PPPPLPLAAAAPPPLNPPTP 73

p53_X_Tropicalis            QMENFAEFSEYP-LAPDMTVLQEG---------------------LMGNT 62

p53_X_laevis                RLDNLSEFPDYP-LAADMTVLQEG---------------------LMGNA 62

p53_Danio_rerio             -EYLPGSFDPN---FFENVLEE------------------QPQPST---- 58

p53_Barbus                  -EYLPSSFDPN---IFDNVLTE------------------QPQPST---- 54

p53_Xiph_maculatus          PPEGLLSQNMD---FWED-----------------------PETMQE--T 54

p53_Xiph_hellerii           PPEGLLSQNMD---FWED-----------------------PETMQE--T 54

p53_Tetraodon_miurus        PAERQMNMMCN---FMDSTFNEALF-------------NLLPEPPSR--D 72

p53_Platichthys_flesus      -AEEFDDHLGN---LLQNGFDMNLF-------------ELPPEMVAK--D 65

p53_Ictalurus               ---IPDDLQEV---PCDVLLSDML----------------QPQSSS---- 65

p53_rainbow_trout           EAPLQVEFDPS---LFEVSATEP-----------------APQPSISTLD 76

p53_Homo_Sapiens            PSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLA 138

p53_Afr_Green_Monk.         PSWPLSSSVPSQKTYHGSYGFRLGFLHSGTAKSVTCTYSPDLNKMFCQLA 138

p53_Mac_Fascicularis        PSWPLSSSVPSQKTYHGSYGFRLGFLHSGTAKSVTCTYSPDLNKMFCQLA 138

p53_Mac_Fuscata             PSWPLSSSVPSQKTYHGSYGFRLGFLHSGTAKSVTCTYSPDLNKMFCQLA 138

p53_Mac__Mulatta            PSWPLSSSVPSQKTYHGSYGFRLGFLHSGTAKSVTCTYSPDLNKMFCQLA 138

p53_Guinea_pig              TSWPLSSSVPSHKPYRGSYGFEVHFLKSGTAKSVTCTYSPGLNKLFCQLA 136

p53_Bugs_Bunny              TSWPLSSSVPSQKTYHGNYGFRLGFLHSGTAKSVTCTYSPCLNKLFCQLA 135

p53_Gold_hamster            TPWPLSSSVPSYKTYQGDYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLA 141

p53_Chinese_hamster         TPWPLSSSVPSYKTFQGDYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLA 138

p53_Gerbil                  ASWPLSSFVPSHKTFQGNYGFRLGFLQSGTAKSVTCTYSPSLNKLFCQLA 131

p53_Rat                     TPWPLSSSVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSISLNKLFCQLA 136

p53_Marmota_monax           TSWPLSSSVPSQNTYPGVYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLA 136

p53_Spalax                  TPWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPPLNKLFCQLA 136

p53_Tree_shrew              PSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPDLNKLFCQLA 138

p53_Mus_musculus            TPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLA 132

p53_Bos_indicus             TSWPLSSFVPSQKTYPGNYGFRLGFLQSGTAKSVTCTYSPSLNKLFCQLA 130

p53_Bos_taurus              TSWPLSSFVPSQKTYPGNYGFRLGFLQSGTAKSVTCTYSPSLNKLFCQLA 130

p53_Sheep                   TSWPLSSFVPSQKTYPGNYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLA 126

p53_Pig                     TSWPLSSFVPSQKTYPGSYDFRLGFLHSGTAKSVTCTYSPALNKLFCQLA 130

p53_Canis_fam               -SWPLSSSVPSPKTYPGTYGFRLGFLHSGTAKSVTWTYSPLLNKLFCQLA 125

p53_Beluga_Whale            TSWPLSSFVPSQKTYPGSYGFHLGFLHSGTAKSVTCTYSPALNKLFCQLA 131

p53_Felix_Catus             ISWPLSSFVPSQKTYPGAYGFHLGFLQSGTAKSVTCTYSPPLNKLFCQLA 130

p53_Galus                   PRAAPSPVVPSTEDYGGDFDFRVGFVEAGTAKSVTCTYSPVLNKVYCRLA 123

p53_X_Tropicalis            VPTVTSSAVPSTEDYAGSYGLKLEFQQNGTAKSVTCTYSTDLNKLFCQLA 112

p53_X_laevis                VPTVTSCAVPSTDDYAGKYGLQLDFQQNGTAKSVTCTYSPELNKLFCQLA 112

p53_Danio_rerio             --LPPTSTVPETSDYPGDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLA 106

p53_Barbus                  --SPPTASVPVATDYPGEHGFKLGFPQSGTAKSVTCTYSSDLNKLFCQLA 102

p53_Xiph_maculatus          KNVPTAPTVPAISNYAGEHGFNLEFNDSGTAKSVTSTYSVKLGKLFCQLA 104

p53_Xiph_hellerii           KNVPTAPTVPAISNYAGEHGFNLEFNDSGTAKSVTSTYSVKLGKLFCQLA 104

p53_Tetraodon_miurus        GANSSSPTVPVTTDYPGEYGFKLRFQKSGTAKSVTSTYSEILNKLYCQLA 122

p53_Platichthys_flesus      SVTPPSSTVPVVTDYPGEYGFQLRFQKSGTAKSVTSTFSELLKKLYCQLA 115

p53_Ictalurus               --SPPTSTVPVTSDYPGLLNFTLHFQESSGTKSVTCTYSPDLNKLFCQLA 113

p53_rainbow_trout           TGSPPTSTVPTTSDYPGALGFQLRFLQSSTAKSVTCTYSPDLNKLFCQLA 126

p53_Homo_Sapiens            KTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSD---- 184

p53_Afr_Green_Monk.         KTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCPHHERCSD---- 184

p53_Mac_Fascicularis        KTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCPHHERCSD---- 184

p53_Mac_Fuscata             KTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCPHHERCSD---- 184

p53_Mac__Mulatta            KTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCPHHERCSD---- 184

p53_Guinea_pig              KTCPVQVWVESPPPPGTRVRALAIYKKSQHMTEVVRRCPHHERCSD---- 182

p53_Bugs_Bunny              KTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSD---- 181

p53_Gold_hamster            KTCPVQLWVSSTPPPGTRVRAMAIYKKLQYMTEVVRRCPHHERSSE---- 187

p53_Chinese_hamster         KTCPVQLWVNSTPPPGTRVRAMAIYKKLQYMTEVVRRCPHHERSSE---- 184

p53_Gerbil                  KTCPVQLWVSSAPPPGTRVRAMAIYKNSQHMTEVVRRCPHHERCSENEAS 181

p53_Rat                     KTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSD---- 182

p53_Marmota_monax           KTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRRCPHHERCSD---- 182

p53_Spalax                  KTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVKRCPHHERCSD---- 182

p53_Tree_shrew              KTCPVQLWVDSAPPPGTRVRAMAIYKQSQYVTEVVRRCPHHERCSD---- 184

p53_Mus_musculus            KTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRC--HHRCS----- 175

p53_Bos_indicus             KTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRCPHHERSSDY--- 177

p53_Bos_taurus              KTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRCPHHERSSDY--- 177

p53_Sheep                   KTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRSPHHERSSDY--- 173

p53_Pig                     KTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTEVVRRCPHHERSSDY--- 177

p53_Canis_fam               KTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVTEVVRRCPHHERCSDS--- 172

p53_Beluga_Whale            KTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTEVVRRCPHHERCSDY--- 178

p53_Felix_Catus             KTCPVQLWVRSPPPPGTCVRAMAIYKKSEFMTEVVRRCPHHERCPDS--- 177

p53_Galus                   KPCPVQVRVGVAPPPGSSLRAVAVYKKSEHVAEVVRRCPHHERCGGG--- 170

p53_X_Tropicalis            KTCPLLVRVERPPPLGSILRATAVYKKSEHVAEVVKRCPHHERSVEP--- 159

p53_X_laevis                KTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVVKRCPHHERSVEP--- 159

p53_Danio_rerio             KTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCPHHERTPD---- 152

p53_Barbus                  KTCPVQMVVNVAPPQGSVIRATAIYKKSEHVAEVVRRCPHHERTPD---- 148

p53_Xiph_maculatus          KTTPIGVLVKEEPPQGAVIRATAVYKKTEHVGEVVKRCPHHQ-------- 146

p53_Xiph_hellerii           KTTPIGVLVKEEPPQGAVIRATSVYKKTEHVGEVVKRCPHHQ-------- 146

p53_Tetraodon_miurus        KTSLVEVLLGKDPPMGAVLRATAIYKKTEHVAEVVRRCPHHQ-------- 164

p53_Platichthys_flesus      KTSPVEVLLSKEPPQGAVLRATAVYKKTEHVADVVRRCPHHQ-------- 157

p53_Ictalurus               KTCPVLMAVSSSPPPGSVLRATAVYKRSEHVAEVVRRCPHHERSND---- 159

p53_rainbow_trout           KTCPVQIVVDHPPPPGAVVRALAIYKKLSDVADVVRRCPHHQSTSE---- 172

p53_Homo_Sapiens            -SDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIH 233

p53_Afr_Green_Monk.         -SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVGSDCTTIH 233

p53_Mac_Fascicularis        -SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVGSDCTTIH 233

p53_Mac_Fuscata             -SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVGSDCTTIH 233

p53_Mac__Mulatta            -SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVGSDCTTIH 233

p53_Guinea_pig              -SDGLAPPQHLIRVEGNLHAEYVDDRTTFRHSVVVPYEPPEVGSDCTTIH 231

p53_Bugs_Bunny              -SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIH 230

p53_Gold_hamster            -GDGLAPPQHLIRVEGNMHAEYLDDKQTFRHSVVVPYEPPEVGSDCTTIH 236

p53_Chinese_hamster         -GDSLAPPQHLIRVEGNLHAEYLDDKQTFRHSVVVPYEPPEVGSDCTTIH 233

p53_Gerbil                  DPRGRAPPQHLIRVEGNLHAEYVDDRQTFRHSVLVPYESPEVGSDCTTIH 231

p53_Rat                     -GDGLAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDYTTIH 231

p53_Marmota_monax           -SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSECTTIH 231

p53_Spalax                  -SDGLAPPQHLIRVEGNLRAEYLDDKHTFRHSVVVPYEPPEVGSDCTTIH 231

p53_Tree_shrew              -SDGLAPPQHLIRVEGNLHAEYSDDRNTFRHSVVVPYEPPEVGSDCTTIH 233

p53_Mus_musculus            -GDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIH 224

p53_Bos_indicus             -SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYESPEIDSECTTIH 226

p53_Bos_taurus              -SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYESPEIDSECTTIH 226

p53_Sheep                   -SDGLAPPQHLIRVEGNLRAEYFDDRNTFRHSVVVPYESPEIESECTTIH 222

p53_Pig                     -SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIH 226

p53_Canis_fam               -SDGLAPPQHLIRVEGNLRAKYLDDRNTFRHSVVVPYEPPEVGSDYTTIH 221

p53_Beluga_Whale            -SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDCTTIH 227

p53_Felix_Catus             -SDGLAPPQHLIRVEGNLHAKYLDDRNTFRHSVVVPYEPPEVGSDCTTIH 226

p53_Galus                   -TDGLAPAQHLIRVEGNPQARYHDDETTKRHSVVVPYEPPEVGSDCTTVL 219

p53_X_Tropicalis            -GDDPAPPSHLMRVEGNSKAYYMEDVGTGRHSVCVPYEGPQVGTECTTVL 208

p53_X_laevis                -GEDAAPPSHLMRVEGNLQAYYMEDVNSGRHSVCVPYEGPQVGTECTTVL 208

p53_Danio_rerio              GDNLAPAGHLIRVEGNQRANYREDNITLRHSVFVPYEAPQLGAEWTTVL 201

p53_Barbus                   GDGLAPAAHLIRVEGNSRALYREDDVNSRHSVVVPYEVPQLGSEFTTVL 197

p53_Xiph_maculatus          SEDLSDNKSHLIRVEGSQLAQYFEDPNTRRHSVTVPYERPQLGSEMTTIL 196

p53_Xiph_hellerii           SEDLSDNKSHLIRVEGSQLAQYFEDPNTRRHSVTVPYERPQLGSEMTTIL 196

p53_Tetraodon_miurus        NEDSAEHRSHLIRMEGSERAQYFEHPHTKRQSVTVPYEPPQLGSEFTTIL 214

p53_Platichthys_flesus      TEDTAEHRSHLIRLEGSQRALYFEDPHTKRQSVTVPYEPPQLGSETTAIL 207

p53_Ictalurus               SSDGPAPPGHLLRVEGNSRAVYQEDGNTQAHSVVVPYEPPQVGSQSTTVL 209

p53_rainbow_trout           NNEGPAPRGHLVRVEGNQRSEYMEDGNTLRHSVLVPYEPPQVGSECTTVL 222

p53_Homo_Sapiens            YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRR 283

p53_Afr_Green_Monk.         YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRR 283

p53_Mac_Fascicularis        YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRR 283

p53_Mac_Fuscata             YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRR 283

p53_Mac__Mulatta            YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRR 283

p53_Guinea_pig              YNYMCNSSCMGGMNRRPILTIITLEDSSGKLLGRDSFEVRVCACPGRDRR 281

p53_Bugs_Bunny              YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRR 280

p53_Gold_hamster            YNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRR 286

p53_Chinese_hamster         YNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRR 283

p53_Gerbil                  YNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRVCACPGRDRR 281

p53_Rat                     YKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRR 281

p53_Marmota_monax           YNYMCNSSCMGGMNRRPILTIITLEGSSGNLLGRNSFEVRVCACPGRDRR 281

p53_Spalax                  YNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRR 281

p53_Tree_shrew              YNYMCNSSCMGGMNRRPILTIITLEDSSGKLLGRNSFEVRICACPGRDRR 283

p53_Mus_musculus            YKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRR 274

p53_Bos_indicus             YNFMCNSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCACPGRDRR 276

p53_Bos_taurus              YNFMCNSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCACPGRDRR 276

p53_Sheep                   YNFMCNSSCMGGMNRRPILTIITLEDSRGNLLGRSSFEVRVCACPGRDRR 272

p53_Pig                     YNFMCNSSCMGGMNRRPILTIITLEDASGNLLGRNSFEVRVCACPGRDRR 276

p53_Canis_fam               YNYMCNSSCMGGMNRRPILTIITLEDSSGNVLGRNSFEVRVCACPGRDRR 271

p53_Beluga_Whale            YNFMCNSSCMGGMNRRPILTIITLEDSNGNLLGRNSFEVRVCACPGRDRR 277

p53_Felix_Catus             YNFMCNSSCMGGMNRRPIITIITLEDSNGKLLGRNSFEVRVCACPGRDRR 276

p53_Galus                   YNFMCNSSCMGGMNRRPILTILTLEGPGGQLLGRRCFEVRVCACPGRDRK 269

p53_X_Tropicalis            YNYMCNSSCMGGMNRRPILTIITLESPEGLLLGRRCFEVRVCACPGRDRR 258

p53_X_laevis                YNYMCNSSCMGGMNRRPILTIITLETPEGLLLGRRCFEVRVCACPGRDRR 258

p53_Danio_rerio             LNYMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPGRDRK 251

p53_Barbus                  YNFMCNSSCMGGMNRRPILTIISLETHDGQLLGRRSFEVRVCACPGRDRK 247

p53_Xiph_maculatus          LSFMCNSSCMGGMNRRPILTILTLETTEGEVLGRRCFEVRVCACPGRDRK 246

p53_Xiph_hellerii           LSFMCNSSCMGGMNRRPILTILTLETTEGEVLGRRCFEVRVCACPGRDRK 246

p53_Tetraodon_miurus        LSFMCNSSCMGGMNRRPILTILTLETQEGIVLGRRCFEVRVCACPGRDRK 264

p53_Platichthys_flesus      LSFMCNSSCMGGMNRRQILTILTLETPDGLVLGRRCFEVRVCACPGRDRK 257

p53_Ictalurus               YNYMCNSSCMGGMNRRPILTIITLETQDGHLLGRRTFEVRVCACPGRDRK 259

p53_rainbow_trout           YNFMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPGRDRK 272

p53_Homo_Sapiens            TEEENLRKKGEP---HHELPPGSTKRALPNNTS-SSPQPKKKP------- 322

p53_Afr_Green_Monk.         TEEENFRKKGEP---CHELPPGSTKRALPNNTS-SSPQPKKKP------- 322

p53_Mac_Fascicularis        TEEENFRKKGEP---CHQLPPGSTKRALPNNTS-SSPQPKKKP------- 322

p53_Mac_Fuscata             TEEENFRKKGEP---CHQLPPGSTKRALPNNTS-SSPQPKKKP------- 322

p53_Mac__Mulatta            TEEENFRKKGEP---CHQLPPGSTKRALPNNTS-SSPQPKKKP------- 322

p53_Guinea_pig              TEEENFRKKGGL---CPEPTPGNIKRALPTSTS-SSPQPKKKP------- 320

p53_Bugs_Bunny              TEEENFRKKGEP---CPELPPGSSKRALPTTTTDSSPQTKKKP------- 320

p53_Gold_hamster            TEEKNFQKKGEP---CPELPPKSAKRALPTNTS-SSPQPKRKT------- 325

p53_Chinese_hamster         TEEKNFQKKGEP---CPELPPKSAKRALPTNTS-SSPPPKKKT------- 322

p53_Gerbil                  TEEENLRKKQ-R---CPELPQGSAKRALPTNTS-SSPQSKRKP------- 319

p53_Rat                     TEEENFRKKEEH---CPELPPGSAKRALPTSTS-SSPQQKKKP------- 320

p53_Marmota_monax           TEEENFRKRGEP---CPEPPPRSTKRALPNGTS-SSPQPKKKP------- 320

p53_Spalax                  TEEENFRKKGEL---CPELPPGSTKRALPTGTS-SSPQPKKKP------- 320

p53_Tree_shrew              TEEENFRKKGES---CPKLPTGSIKRALPTGSS-SSPQPKKKP------- 322

p53_Mus_musculus            TEEENFRKKEVL---CPELPPGSAKRALPTCTS-ASPPQKKKP------- 313

p53_Bos_indicus             TEEENLRKKGQS---CPEPPPRSTKRALPTNTS-SSPQPKKKP------- 315

p53_Bos_taurus              TEEENLRKKGQS---CPEPPPRSTKRALPTNTS-SSPQPKKKP------- 315

p53_Sheep                   TEEENFRKKGQS---CPEPPPGSTKRALPSSTS-SSPQQKKKP------- 311

p53_Pig                     TEEENFLKKGQS---CPEPPPGSTKRALPTSTS-SSPVQKKKP------- 315

p53_Canis_fam               TEEENFHKKGEP---CPEPPPGSTKRALPPSTS-SSPPQKKKP------- 310

p53_Beluga_Whale            TEEENFHKKGQS---CPELPTGSAKRALPTGTS-SSPPQKKKP------- 316

p53_Felix_Catus             TEEENFRKKGEP---CPEPPPGSTKRALPPSTS-STPPQKKKP------- 315

p53_Galus                   IEEENFRKRG--------GAGGVAKRAMSPPTEAPEPPKKRVLN------ 305

p53_X_Tropicalis            TEEDNCTKKRGL---KP-----NGKRELSHPPSSDPPLPKKRLV-----E 295

p53_X_laevis                TEEDNYTKKRGL---KP-----SGKRELAHPPSSEPPLPKKRLV-----V 295

p53_Danio_rerio             TEESNFKKDQET--KTMAKTTTGTKRSLVKESSSATLRPEGSKKAKGS-- 297

p53_Barbus                  TEESNFRKDQET--KTLDKIPSANKRSLTKDSTSSVPRPEGSKKAKLSG- 294

p53_Xiph_maculatus          TEEGNL-------EKS--GTKQTKKRKSAPA---PDTSTAKKSKSASSGE 284

p53_Xiph_hellerii           TEEGNL-------EKS--GTKQTKKRKSAPA---PDTSTAKKSKSASSGE 284

p53_Tetraodon_miurus        TEETNS-------TKMQNDAKDAKKRKSVPT---PDSTTIKKSKTASSAE 304

p53_Platichthys_flesus      TDEESS-------TKTPNGPKQTKKRKQAPSNSAPHTTTVMKSKSSSSAE 300

p53_Ictalurus               TEESNFKKQQEP--KTSGKTLT--KRSMKDPPS----HPEASKKSKNS-- 299

p53_rainbow_trout           TEEINLKKQQETTLETKTKPAQGIKRAMK-EASLPAPQPGASKKTKSSPA 321

p53_Homo_Sapiens            -LDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLK- 370

p53_Afr_Green_Monk.         -LDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPAGSRAHSSHLK- 370

p53_Mac_Fascicularis        -LDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPAGSRAHSSHLK- 370

p53_Mac_Fuscata             -LDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPAGSRAHSSHLK- 370

p53_Mac__Mulatta            -LDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPAGSRAHSSHLK- 370

p53_Guinea_pig              -LDAEYFTLKIRGRKNFEILREINEALEFKDAQTEKEPGESRPHSSYPK- 368

p53_Bugs_Bunny              -LDGEYFILKIRGRERFEMFRELNEALELKDAQAEKEPGGSRAHSSYLK- 368