p53 Information

p53 information

p53 story

p53 monoclonal antibodies

p53 pathways

p53 gene

p53 protein(s)

mdm family

p63/p73 protein(s)

p53 evolution

p53 polymorphism

p53 and cancer

mouse models

p53 Alignment

Alignment of rodent p53 proteins unsing ClustalW: only full-length proteins have been used.
A pdf document with this alignment is available -> pdf

Rodent p53

p53_Mus_musculus     MEESQSDISLELPLSQETFSGLWKLLPPEDILP-----SPHCMDDLLLP-QDVEEFFEGP 54

p53_Guinea_pig       MEEPHSDLSIEPPLSQETFSDLWKLLPENNVLSD--SLSP-PMDHLLLSPEEVASWLGEN 57

p53_Bugs_Bunny       MEESQSDLSLEPPLSQETFSDLWKLLPENNLLTT--SLNP-PVDD-LLSAEDVANWLNED 56

p53_Gold_hamster     MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLST--LPSSDSIEELFLS-ENVAGWLEDP 57

p53_Chinese_hamster  MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLST--LPSSDSIEELFLS-ENVTGWLEDS 57

p53_Gerbil           MEEPQSDLSIEPPLSQETFSDLWKLLPPKNLLSA-----LEPMEDLLLP-QDVTSWLGDA 54

p53_Rat              MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATGSPNSMEDLFLP-QDVAELLEGP 59

p53_Marmota_monax    MEEAQSDLSIEPPLSQETFSDLWNLLPENNVLSP--VLSP-PMDDLLLSSEDVENWFDKG 57

p53_Spalax           MEEQQSDLSIEPPLSQETFSDLWKLLPQNNVLST--PLSPNSMEDLLLSPEDVANWL-DD 57

p53_Tree_shrew       MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSP--LPSQ-AMDDLMLSPDDIEQWFTED 57

p53_Mus_musculus    S---EA---LRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFL 108

p53_Guinea_pig      P--DGD---GHVSAAPVSEAPTSAGPALVAPAPATSWPLSSSVPSHKPYRGSYGFEVHFL 112

p53_Bugs_Bunny      P--EEG---LRVPAAPAPEAPAPAAPALAAPAPATSWPLSSSVPSQKTYHGNYGFRLGFL 111

p53_Gold_hamster    GEALQGSAAAAAPAAPAAEDPVAETPAPVASAPATPWPLSSSVPSYKTYQGDYGFRLGFL 117

p53_Chinese_hamster GGALQG---VAAAAASTAEDPVTETPAPVASAPATPWPLSSSVPSYKTFQGDYGFRLGFL 114

p53_Gerbil          D---EA---LPVCTAPAEG-PAPEAPAPAAPAPPASWPLSSFVPSHKTFQGNYGFRLGFL 107

p53_Rat             E---EA---LQVS-APAAQEPGTEAPAPVAPASATPWPLSSSVPSQKTYQGNYGFHLGFL 112

p53_Marmota_monax   P--DEA---LQMSAAPAPKAPTPAASTLAAPSPATSWPLSSSVPSQNTYPGVYGFRLGFL 112

p53_Spalax          P--DEA---LQVPAAAITGDPVTETSAPVAPPPATPWPLSSSVPSQKTYQGSYGFRLGFL 112

p53_Tree_shrew      PGPDEA---PRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFL 114

p53_Mus_musculus    QSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVR 168

p53_Guinea_pig      KSGTAKSVTCTYSPGLNKLFCQLAKTCPVQVWVESPPPPGTRVRALAIYKKSQHMTEVVR 172

p53_Bugs_Bunny      HSGTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVR 171

p53_Gold_hamster    HSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVSSTPPPGTRVRAMAIYKKLQYMTEVVR 177

p53_Chinese_hamster HSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVNSTPPPGTRVRAMAIYKKLQYMTEVVR 174

p53_Gerbil          QSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVSSAPPPGTRVRAMAIYKNSQHMTEVVR 167

p53_Rat             QSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVR 172

p53_Marmota_monax   HSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVR 172

p53_Spalax          HSGTAKSVTCTYSPPLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVK 172

p53_Tree_shrew      HSGTAKSVTCTYSPDLNKLFCQLAKTCPVQLWVDSAPPPGTRVRAMAIYKQSQYVTEVVR 174

p53_Mus_musculus    RC--HHRCS------GDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEY 220

p53_Guinea_pig      RCPHHERCSD-----SDGLAPPQHLIRVEGNLHAEYVDDRTTFRHSVVVPYEPPEVGSDC 227

p53_Bugs_Bunny      RCPHHERCSD-----SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSDC 226

p53_Gold_hamster    RCPHHERSSE-----GDGLAPPQHLIRVEGNMHAEYLDDKQTFRHSVVVPYEPPEVGSDC 232

p53_Chinese_hamster RCPHHERSSE-----GDSLAPPQHLIRVEGNLHAEYLDDKQTFRHSVVVPYEPPEVGSDC 229

p53_Gerbil          RCPHHERCSENEASDPRGRAPPQHLIRVEGNLHAEYVDDRQTFRHSVLVPYESPEVGSDC 227

p53_Rat             RCPHHERCSD-----GDGLAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVGSDY 227

p53_Marmota_monax   RCPHHERCSD-----SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVGSEC 227

p53_Spalax          RCPHHERCSD-----SDGLAPPQHLIRVEGNLRAEYLDDKHTFRHSVVVPYEPPEVGSDC 227

p53_Tree_shrew      RCPHHERCSD-----SDGLAPPQHLIRVEGNLHAEYSDDRNTFRHSVVVPYEPPEVGSDC 229

p53_Mus_musculus    TTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENF 280

p53_Guinea_pig      TTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGKLLGRDSFEVRVCACPGRDRRTEEENF 287

p53_Bugs_Bunny      TTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENF 286

p53_Gold_hamster    TTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRRTEEKNF 292

p53_Chinese_hamster TTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRRTEEKNF 289

p53_Gerbil          TTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRVCACPGRDRRTEEENL 287

p53_Rat             TTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENF 287

p53_Marmota_monax   TTIHYNYMCNSSCMGGMNRRPILTIITLEGSSGNLLGRNSFEVRVCACPGRDRRTEEENF 287

p53_Spalax          TTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENF 287

p53_Tree_shrew      TTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGKLLGRNSFEVRICACPGRDRRTEEENF 289

p53_Mus_musculus    RKKEVLCPELPPGSAKRALPTCTS-ASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEAL 339

p53_Guinea_pig      RKKGGLCPEPTPGNIKRALPTSTS-SSPQPKKKPLDAEYFTLKIRGRKNFEILREINEAL 346

p53_Bugs_Bunny      RKKGEPCPELPPGSSKRALPTTTTDSSPQTKKKPLDGEYFILKIRGRERFEMFRELNEAL 346

p53_Gold_hamster    QKKGEPCPELPPKSAKRALPTNTS-SSPQPKRKTLDGEYFTLKIRGQERFKMFQELNEAL 351

p53_Chinese_hamster QKKGEPCPELPPKSAKRALPTNTS-SSPPPKKKTLDGEYFTLKIRGHERFKMFQELNEAL 348

p53_Gerbil          RKK-QRCPELPQGSAKRALPTNTS-SSPQSKRKPADGEYFTLKIRGRKRFEVFRELNEAL 345

p53_Rat             RKKEEHCPELPPGSAKRALPTSTS-SSPQQKKKPLDGEYFTLKIRGRERFEMFRELNEAL 346

p53_Marmota_monax   RKRGEPCPEPPPRSTKRALPNGTS-SSPQPKKKPLDGEYFTLKIRGRARFEMFQELNEAL 346

p53_Spalax          RKKGELCPELPPGSTKRALPTGTS-SSPQPKKKPLDGEYFTLKIRGRERFEMFRELNEAL 346

p53_Tree_shrew      RKKGESCPKLPTGSIKRALPTGSS-SSPQPKKKPLDEEYFTLQIRGRERFEMLREINEAL 348

p53_Mus_musculus         ELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD 384

p53_Guinea_pig           EFKDAQTEKEPGESRPHSSYPKSKKGQSTSCHKKLMFKREGLDSD 391

p53_Bugs_Bunny           ELKDAQAEKEPGGSRAHSSYLKAKKGQSTSRHKKPMFKREGPDSD 391

p53_Gold_hamster         ELKDAQALKASEDSGAHSSYLKSKKGQSASRLKKLMIKREGPDSD 396

p53_Chinese_hamster      ELKDAQASKGSEDNGAHSSYLKSKKGQSASRLKKLMIKREGPDSD 393

p53_Gerbil               ELKDAQAAGESGDGRAQASCLKTKKDKSTSPRKNPMIKREEPDSD 390

p53_Rat                  ELKDARAAEESGDSRAHSSYPKTKKGQSTSRHKKPMIKKVGPDSD 391

p53_Marmota_monax        ELKDAQAEKEPGESRPHPSYLKSKKGQSTSRHKKIIFKREGPDSD 391

p53_Spalax               ELKDTQAEKDSGESRAHSSYLKSKKGQSTSRHKKLMIKREGPDSD 391

p53_Tree_shrew           ELKDAMAGKESAGSRAHSSHLKSKKGQSTSRHRKLMFKTEGPDSD 393