|
|
|
|
|
|
|
|
|
|
||||||
|
|
|
|
|
|
|
|
p53 Informationp53 protein(s)p63/p73 protein(s)p53 evolution
p53 polymorphismp53 and cancer
|
p53 AlignmentAlignment of mammalian p53 proteins unsing ClustalW: only full-length proteins have been used.
Homo_Sapiens MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSP--LPS-QAMDDLMLSPDDIEQWFTED 57
Afr_Green_Monk. MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSP--LPS-QAVDDLMLSPDDLAQWLTED 57
Mac_Fascicularis MEEPQSDPSIEPPLSQETFSDLWKLLPENHVLSP--LPS-QAVDDLMLSPDDLAQWLTED 57
Mac_Fuscata MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSP--LPS-QAVDDLMLSPDDLAQWLTED 57
Mac__Mulatta MEEPQSDPSIEPPLSQETFSDLWKLLPENNVLSP--LPS-QAVDDLMLSPDDLAQWLTED 57
Guinea_pig MEEPHSDLSIEPPLSQETFSDLWKLLPENNVLSD--SLS-PPMDHLLLSPEEVASWLGEN 57
Bugs_Bunny MEESQSDLSLEPPLSQETFSDLWKLLPENNLLTT--SLN-PPVDDLLSA-EDVANWLNED 56
Gold_hamster MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLSTLP--SSDSIEELFLS-ENVAGWLEDP 57
Chinese_hamster MEEPQSDLSIELPLSQETFSDLWKLLPPNNVLSTLP--SSDSIEELFLS-ENVTGWLEDS 57
Gerbil MEEPQSDLSIEPPLSQETFSDLWKLLPPKNLLS-----ALEPMEDLLLP-QDVTSWLGDA 54
Rat MEDSQSDMSIELPLSQETFSCLWKLLPPDDILPTTATGSPNSMEDLFLP-QDVAELLEGP 59
Marmota_monax MEEAQSDLSIEPPLSQETFSDLWNLLPENNVLSP--VLS-PPMDDLLLSSEDVENWFDKG 57
Spalax MEEQQSDLSIEPPLSQETFSDLWKLLPQNNVLST--PLSPNSMEDLLLSPEDVANWLDDP 58
Tree_shrew MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSP--LPS-QAMDDLMLSPDDIEQWFTED 57
Mus_musculus MEESQSDISLELPLSQETFSGLWKLLPPEDILP-----SPHCMDDLLLP-QDVEEFFEGP 54
Bos_indicus MEESQAELNVEPPLSQETFSDLWNLLPENNLLSS--ELS-APVDDLLPY-TDVATWLDEC 56
Bos_taurus MEESQAELNVEPPLSQETFSDLWNLLPENNLLSS--ELS-APVDDLLPY-TDVATWLDEC 56
Sheep MEESQAELGVEPPLSQETFSDLWNLLPENNLLSS--ELS-APVDDLLPYSEDVVTWLDEC 57
Pig MEESQSELGVEPPLSQETFSDLWKLLPENNLLSS--ELSLAAVNDLLLSP--VTNWLDEN 56
Canis_fam MEESQSELNIDPPLSQETFSELWNLLPENNVLSS--ELC-PAVDELLLP-ESVVNWLDED 56
Beluga_Whale MEESQAELGVEPPLSQETFSDLWKLLPENNLLSS--ELS-PAVDDLLLSPEDVANWLDER 57
Felix_Catus MQEPPLELTIEPPLSQETFSELWNLLPENNVLSS--ELS-SAMNELPLS-EDVANWLDEA 56
Homo_Sapiens PGPDEAPRMPE------AAPRVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRL 111
Afr_Green_Monk. PGPDEAPRMSE------AAPHMAPTPAAPTPAAPAPAPSWPLSSSVPSQKTYHGSYGFRL 111
Mac_Fascicularis PGPDEAPRMSE------AAPPMAPTPAAPTPAAPAPAPSWPLSSSVPSQKTYHGSYGFRL 111
Mac_Fuscata PGPDEAPRMSE------AAPPMAPTPAAPTPAAPAPAPSWPLSSSVPSQKTYHGSYGFRL 111
Mac__Mulatta PGPDEAPRMSE------AAPPMAPTPAAPTPAAPAPAPSWPLSSSVPSQKTYHGSYGFRL 111
Guinea_pig P--DGDGHVSA------APVSEAPTSAGPALVAPAPATSWPLSSSVPSHKPYRGSYGFEV 109
Bugs_Bunny P--EEGLRVPA------APAPEAPAPAAPALAAPAPATSWPLSSSVPSQKTYHGNYGFRL 108
Gold_hamster G---EALQGSAAAAAPAAPAAEDPVAETPAPVASAPATPWPLSSSVPSYKTYQGDYGFRL 114
Chinese_hamster G---GALQG---VAAAAASTAEDPVTETPAPVASAPATPWPLSSSVPSYKTFQGDYGFRL 111
Gerbil D---EALPVCT------APAEG-PAPEAPAPAAPAPPASWPLSSFVPSHKTFQGNYGFRL 104
Rat E---EALQVS-------APAAQEPGTEAPAPVAPASATPWPLSSSVPSQKTYQGNYGFHL 109
Marmota_monax P--DEALQMSA------APAPKAPTPAASTLAAPSPATSWPLSSSVPSQNTYPGVYGFRL 109
Spalax D---EALQVPA------AAITGDPVTETSAPVAPPPATPWPLSSSVPSQKTYQGSYGFRL 109
Tree_shrew PGPDEAPRMPE------AAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRL 111
Mus_musculus S---EALRVSG------APAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHL 105
Bos_indicus P--NEAPQMPE------PS-----APAAPPPATPAPATSWPLSSFVPSQKTYPGNYGFRL 103
Bos_taurus P--NEAPQMPE------PS-----APAAPPPATPAPATSWPLSSFVPSQKTYPGNYGFRL 103
Sheep P--NEAPQMPE------P----------PAQAALAPATSWPLSSFVPSQKTYPGNYGFRL 99
Pig P--DDASRVPA------PP-----AATAPAPAAPAPATSWPLSSFVPSQKTYPGSYDFRL 103
Canis_fam S--DDAPRMPA------TS-----APTAPGPAP-----SWPLSSSVPSPKTYPGTYGFRL 98
Beluga_Whale P--DEAPQMPE------PP-----APAAPTPAAPAPATSWPLSSFVPSQKTYPGSYGFHL 104
Felix_Catus P--DDASGMSA------VP-----APAAPAPATPAPAISWPLSSFVPSQKTYPGAYGFHL 103
Homo_Sapiens GFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTE 171
Afr_Green_Monk. GFLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTE 171
Mac_Fascicularis GFLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTE 171
Mac_Fuscata GFLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTE 171
Mac__Mulatta GFLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTE 171
Guinea_pig HFLKSGTAKSVTCTYSPGLNKLFCQLAKTCPVQVWVESPPPPGTRVRALAIYKKSQHMTE 169
Bugs_Bunny GFLHSGTAKSVTCTYSPCLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTE 168
Gold_hamster GFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVSSTPPPGTRVRAMAIYKKLQYMTE 174
Chinese_hamster GFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVNSTPPPGTRVRAMAIYKKLQYMTE 171
Gerbil GFLQSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVSSAPPPGTRVRAMAIYKNSQHMTE 164
Rat GFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTE 169
Marmota_monax GFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTE 169
Spalax GFLHSGTAKSVTCTYSPPLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTE 169
Tree_shrew GFLHSGTAKSVTCTYSPDLNKLFCQLAKTCPVQLWVDSAPPPGTRVRAMAIYKQSQYVTE 171
Mus_musculus GFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTE 165
Bos_indicus GFLQSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTE 163
Bos_taurus GFLQSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTE 163
Sheep GFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTE 159
Pig GFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTE 163
Canis_fam GFLHSGTAKSVTWTYSPLLNKLFCQLAKTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVTE 158
Beluga_Whale GFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTE 164
Felix_Catus GFLQSGTAKSVTCTYSPPLNKLFCQLAKTCPVQLWVRSPPPPGTCVRAMAIYKKSEFMTE 163
Homo_Sapiens VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVG 226
Afr_Green_Monk. VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVG 226
Mac_Fascicularis VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVG 226
Mac_Fuscata VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVG 226
Mac__Mulatta VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLRVEYSDDRNTFRHSVVVPYEPPEVG 226
Guinea_pig VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLHAEYVDDRTTFRHSVVVPYEPPEVG 224
Bugs_Bunny VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVG 223
Gold_hamster VVRRCPHHERSSE-----GDGLAPPQHLIRVEGNMHAEYLDDKQTFRHSVVVPYEPPEVG 229
Chinese_hamster VVRRCPHHERSSE-----GDSLAPPQHLIRVEGNLHAEYLDDKQTFRHSVVVPYEPPEVG 226
Gerbil VVRRCPHHERCSENEASDPRGRAPPQHLIRVEGNLHAEYVDDRQTFRHSVLVPYESPEVG 224
Rat VVRRCPHHERCSD-----GDGLAPPQHLIRVEGNPYAEYLDDRQTFRHSVVVPYEPPEVG 224
Marmota_monax VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVG 224
Spalax VVKRCPHHERCSD-----SDGLAPPQHLIRVEGNLRAEYLDDKHTFRHSVVVPYEPPEVG 224
Tree_shrew VVRRCPHHERCSD-----SDGLAPPQHLIRVEGNLHAEYSDDRNTFRHSVVVPYEPPEVG 226
Mus_musculus VVRRC--HHRCS------GDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAG 217
Bos_indicus VVRRCPHHERSSDY----SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYESPEID 219
Bos_taurus VVRRCPHHERSSDY----SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYESPEID 219
Sheep VVRRSPHHERSSDY----SDGLAPPQHLIRVEGNLRAEYFDDRNTFRHSVVVPYESPEIE 215
Pig VVRRCPHHERSSDY----SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVG 219
Canis_fam VVRRCPHHERCSDS----SDGLAPPQHLIRVEGNLRAKYLDDRNTFRHSVVVPYEPPEVG 214
Beluga_Whale VVRRCPHHERCSDY----SDGLAPPQHLIRVEGNLRAEYLDDRNTFRHSVVVPYEPPEVG 220
Felix_Catus VVRRCPHHERCPDS----SDGLAPPQHLIRVEGNLHAKYLDDRNTFRHSVVVPYEPPEVG 219
Homo_Sapiens SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEE 286
Afr_Green_Monk. SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEE 286
Mac_Fascicularis SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEE 286
Mac_Fuscata SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEE 286
Mac__Mulatta SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEE 286
Guinea_pig SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGKLLGRDSFEVRVCACPGRDRRTEE 284
Bugs_Bunny SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEE 283
Gold_hamster SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRRTEE 289
Chinese_hamster SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRICACPGRDRRTEE 286
Gerbil SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDPSGNLLGRNSFEVRVCACPGRDRRTEE 284
Rat SDYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEE 284
Marmota_monax SECTTIHYNYMCNSSCMGGMNRRPILTIITLEGSSGNLLGRNSFEVRVCACPGRDRRTEE 284
Spalax SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEE 284
Tree_shrew SDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGKLLGRNSFEVRICACPGRDRRTEE 286
Mus_musculus SEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEE 277
Bos_indicus SECTTIHYNFMCNSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCACPGRDRRTEE 279
Bos_taurus SECTTIHYNFMCNSSCMGGMNRRPILTIITLEDSCGNLLGRNSFEVRVCACPGRDRRTEE 279
Sheep SECTTIHYNFMCNSSCMGGMNRRPILTIITLEDSRGNLLGRSSFEVRVCACPGRDRRTEE 275
Pig SDCTTIHYNFMCNSSCMGGMNRRPILTIITLEDASGNLLGRNSFEVRVCACPGRDRRTEE 279
Canis_fam SDYTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNVLGRNSFEVRVCACPGRDRRTEE 274
Beluga_Whale SDCTTIHYNFMCNSSCMGGMNRRPILTIITLEDSNGNLLGRNSFEVRVCACPGRDRRTEE 280
Felix_Catus SDCTTIHYNFMCNSSCMGGMNRRPIITIITLEDSNGKLLGRNSFEVRVCACPGRDRRTEE 279
Homo_Sapiens ENLRKKGEPHHELPPGSTKRALPNNTS-SSPQPKKKPLDGEYFTLQIRGRERFEMFRELN 345
Afr_Green_Monk. ENFRKKGEPCHELPPGSTKRALPNNTS-SSPQPKKKPLDGEYFTLQIRGRERFEMFRELN 345
Mac_Fascicularis ENFRKKGEPCHQLPPGSTKRALPNNTS-SSPQPKKKPLDGEYFTLQIRGRERFEMFRELN 345
Mac_Fuscata ENFRKKGEPCHQLPPGSTKRALPNNTS-SSPQPKKKPLDGEYFTLQIRGRERFEMFRELN 345
Mac__Mulatta ENFRKKGEPCHQLPPGSTKRALPNNTS-SSPQPKKKPLDGEYFTLQIRGRERFEMFRELN 345
Guinea_pig ENFRKKGGLCPEPTPGNIKRALPTSTS-SSPQPKKKPLDAEYFTLKIRGRKNFEILREIN 343
Bugs_Bunny ENFRKKGEPCPELPPGSSKRALPTTTTDSSPQTKKKPLDGEYFILKIRGRERFEMFRELN 343
Gold_hamster KNFQKKGEPCPELPPKSAKRALPTNTS-SSPQPKRKTLDGEYFTLKIRGQERFKMFQELN 348
Chinese_hamster KNFQKKGEPCPELPPKSAKRALPTNTS-SSPPPKKKTLDGEYFTLKIRGHERFKMFQELN 345
Gerbil ENLRKKQ-RCPELPQGSAKRALPTNTS-SSPQSKRKPADGEYFTLKIRGRKRFEVFRELN 342
Rat ENFRKKEEHCPELPPGSAKRALPTSTS-SSPQQKKKPLDGEYFTLKIRGRERFEMFRELN 343
Marmota_monax ENFRKRGEPCPEPPPRSTKRALPNGTS-SSPQPKKKPLDGEYFTLKIRGRARFEMFQELN 343
Spalax ENFRKKGELCPELPPGSTKRALPTGTS-SSPQPKKKPLDGEYFTLKIRGRERFEMFRELN 343
Tree_shrew ENFRKKGESCPKLPTGSIKRALPTGSS-SSPQPKKKPLDEEYFTLQIRGRERFEMLREIN 345
Mus_musculus ENFRKKEVLCPELPPGSAKRALPTCTS-ASPPQKKKPLDGEYFTLKIRGRKRFEMFRELN 336
Bos_indicus ENLRKKGQSCPEPPPRSTKRALPTNTS-SSPQPKKKPLDGEYFTLQIRGFKRYEMFRELN 338
Bos_taurus ENLRKKGQSCPEPPPRSTKRALPTNTS-SSPQPKKKPLDGEYFTLQIRGFKRYEMFRELN 338
Sheep ENFRKKGQSCPEPPPGSTKRALPSSTS-SSPQQKKKPLDGEYFTLQIRGRKRFEMFRELN 334
Pig ENFLKKGQSCPEPPPGSTKRALPTSTS-SSPVQKKKPLDGEYFTLQIRGRERFEMFRELN 338
Canis_fam ENFHKKGEPCPEPPPGSTKRALPPSTS-SSPPQKKKPLDGEYFTLQIRGRERYEMFRNLN 333
Beluga_Whale ENFHKKGQSCPELPTGSAKRALPTGTS-SSPPQKKKPLDGEYFTLQIRGRERFEMFRELN 339
Felix_Catus ENFRKKGEPCPEPPPGSTKRALPPSTS-STPPQKKKPLDGEYFTLQIRGRERFEMFRELN 338
Homo_Sapiens EALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD 393
Afr_Green_Monk. EALELKDAQAGKEPAGSRAHSSHLKSKKGQSTSRHKKFMFKTEGPDSD 393
Mac_Fascicularis EALELKDAQAGKEPAGSRAHSSHLKSKKGQSTSRHKKFMFKTEGPDSD 393
Mac_Fuscata EALELKDAQAGKEPAGSRAHSSHLKSKKGQSTSRHKKFMFKTEGPDSD 393
Mac__Mulatta EALELKDAQAGKEPAGSRAHSSHLKSKKGQSTSRHKKFMFKTEGPDSD 393
Guinea_pig EALEFKDAQTEKEPGESRPHSSYPKSKKGQSTSCHKKLMFKREGLDSD 391
Bugs_Bunny EALELKDAQAEKEPGGSRAHSSYLKAKKGQSTSRHKKPMFKREGPDSD 391
Gold_hamster EALELKDAQALKASEDSGAHSSYLKSKKGQSASRLKKLMIKREGPDSD 396
Chinese_hamster EALELKDAQASKGSEDNGAHSSYLKSKKGQSASRLKKLMIKREGPDSD 393
Gerbil EALELKDAQAAGESGDGRAQASCLKTKKDKSTSPRKNPMIKREEPDSD 390
Rat EALELKDARAAEESGDSRAHSSYPKTKKGQSTSRHKKPMIKKVGPDSD 391
Marmota_monax EALELKDAQAEKEPGESRPHPSYLKSKKGQSTSRHKKIIFKREGPDSD 391
Spalax EALELKDTQAEKDSGESRAHSSYLKSKKGQSTSRHKKLMIKREGPDSD 391
Tree_shrew EALELKDAMAGKESAGSRAHSSHLKSKKGQSTSRHRKLMFKTEGPDSD 393
Mus_musculus EALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD 384
Bos_indicus DALELKDALDGREPGESRAHSSHLKSKKRPSPSCHKKPMLKREGPDSD 386
Bos_taurus DALELKDALDGREPGESRAHSSHLKSKKRPSPSCHKKPMLKREGPDSD 386
Sheep EALELMDAQAGREPGESRAHSSHLKSKKGPSPSCHKKPMLKREGPDSD 382
Pig DALELKDAQTARESGENRAHSSHLKSKKGQSPSRHKKPMFKREGPDSD 386
Canis_fam EALELKDAQSGKEPGGSRAHSSHLKAKKGQSTSRHKKLMFKREGLDSD 381
Beluga_Whale EALELKDAQAGKEPGESRAHSSHLKSKKGQSPSRHKKLMFKREGPDSD 387
Felix_Catus EALELKDAQSGKEPGGSRAHSSHLKAKKGQSTSRHKKPMLKREGLDSD 386
|
 |
Home | Our Work |p53 Info| p53 Database | p53 Link | Contact us |
