Cell lines database

p53 database

p53 mutations in cell lines

The hanbook of p53 mutation in cell lines

Cell lines with a controversial p53 status

The NCI 60 panel

Bladder cancer cell lines

Brain cancer cell lines

Breast cancer cell lines

Cervical carcinoma

Colorectal cancer cell lines

Esophageal cancer cell lines

Gastric cancer cell lines

Head and Neck cancer cell lines

Leukemia / Lymphoma cell lines

NSCLC cancer cell lines

Ovarian cancer cell lines

Pancreatic cancer cell lines

Sarcoma cell lines

SCLC cancer cell lines

Melanoma cell lines

Hepatocellular carcinoma

References

Small Cell Lung Cancer

Table I : cell lines with wt p53

Cell line ATCC Reference
SBC-3   1006
Lu24   1382
MS-18   1382
NCI-H209 HTB-172 1382
NCI-H128 HTB-120 2249
NCI-H1522 CRL-5874 2249
NCI-H2081 CRL-5920 2249
NCI-H446 HTB-171 2249
NCI-H711 CRL-5836 678
NCI-H748 CRL-5841 678

Table II : cell lines with p53 gene deletion or rearrangement

No data

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

Cell line ATCC Mutation reference
NCI-H1694 CRL-5888 c.783-1G>T 2249
NCI-H2227 CRL-5934 c.783-2A>C 678
NCI-H526 CRL-5811 splice intron3 678

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)

 

Pos.
WT
Mut
      AA
Mut
Comp
Name
NB
Ref
Comments
126 TAC TGC Tyr Cys SM ACC-LC-172 17 1976 Single report
249 AGG AGT Arg Ser SM ACC-LC-48 389 1976 Single report
110 CGT del1 Arg Fs. SM ACC-LC-49 3 1976 Single report
152 CCG ins1 Pro Fs. SM ACC-LC-80 8 1976 Single report
245 GGC TGC Gly Cys SM COLO-668 86 2249 Mutation in COSMIC database
306 CGA TGA Arg Stop SM COR-L51 160 2249 Mutation in COSMIC database
281 GAC CAC Asp His SM COR-L96CAR 41 2249 Mutation in COSMIC database
245 GGC GTC Gly Val SM CPC-N 84 2249 Mutation in COSMIC database
155 ACC CCC Thr Pro SM DMS-153 20 1953 wt in COSMIC
245 GGC TGC Gly Cys SM DMS-273 86 2249 Mutation in COSMIC database
241 TCC TTC Ser Phe SM DMS-53 101 2249 Mutation in COSMIC database
278 CCT del2c Pro Fs. SM DMS-79 1 2249 Mutation in COSMIC database. del2 and ins 1
237 ATG ATA Met Ile SM DMS-92 123 16 Single report
273 CGT CTT Arg Leu SM GLC14 147 1386 Single report
282 CGG TGG Arg Trp SM GLC28 600 1386 Single report
53 TGG TGA Trp Stop SM GLC3 7 1386 Single report
146 TGG TAG Trp Stop DMU GLC35 46 1386 Single report
175 CGC CAC Arg His DMU GLC35 1187 1386 Single report
158 CGC CTC Arg Leu SM GLC36 92 1386 Single report
132 AAG GAG Lys Glu SM GLC4 25 1386 Single report
332 ATC del1c Ile Fs. SM GLC42 4 1386 Single report
326 GAA TAA Glu Stop SM GLC44 9 1386 Single report
218 GTG GGG Val Gly SM GLC45 11 1386 Single report
144 CAG CCG Gln Pro SM GLC7 10 1386 Single report
280 AGA GGA Arg Gly SM GLC8 40 1386 Single report
193 CAT CTT His Leu SM HOV 55 1386 Single report
294 GAG TAG Glu Stop SM IST-SL2 54 2249 Mutation in COSMIC database
294 GAG del1a Glu Fs. SM LB647-SCLC 1 2249 Mutation in COSMIC database
278 CCT CTT Pro Leu SM LU-130 84 1382 Single report
278 CCT CTT Pro Leu SM LU-134-A 84 364 Single report
244 GGC TGC Gly Cys SM LU-135 53 364 Single report
248 CGG CTG Arg Leu SM LU-138 124 1382 Single report
157 GTC TTC Val Phe SM LU-139 177 364 Single report
342 CGA del1b Arg Fs. SM LU-140 1 1382 Single report
179 CAT TAT His Tyr SM LU-141 128 1382 Single report
156 CGC del13c Arg Fs. SM LU-165 1 2249 Mutation in COSMIC database
244 GGC AGC Gly Ser SM MS-1 72 2242 Single report
298 GAG TAG Glu Stop SM N230 71 1382 Single report
298 GAG TAG Glu Stop SM N231 71 1382 Single report
46 TCC del1b Ser Fs. DMU NCI-H1048 1 2249 Controversy with other publications
273 CGT TGT Arg Cys SM NCI-H1048 687 22 Controversy with other publications
273 CGT TGT Arg Cys DMU NCI-H1048 687 2249 Controversy with other publications
249 AGG AGT Arg Ser SM NCI-H1105 389 2249 Mutation in COSMIC database
334 GGG GTG Gly Val SM NCI-H1184 3 22 Single report
175 CGC del1b Arg Fs. SM NCI-H1417 2 678 wt in COSMIC
179 CAT CAG His Gln SM NCI-H1436 14 678 wt in COSMIC
194 CTT CGT Leu Arg SM NCI-H1450 66 17 Single report
318 CCA del19b Pro Fs. SM NCI-H146 1 2249 Mutation in COSMIC database
68 GAG TAG Glu Stop SM NCI-H1514 5 22 Single report
151 CCC CAC Pro His SM NCI-H1607 33 22 Single report
248 CGG CTG Arg Leu SM NCI-H1618 124 22 wt in COSMIC
266 GGA GTA Gly Val SM NCI-H1672 51 22 Single report
241 TCC TGC Ser Cys SM NCI-H187 36 1712 Single report
273 CGT CTT Arg Leu SM NCI-H1881 147 22 Single report
273 CGT CTT Arg Leu SM NCI-H1882 147 678 wt in COSMIC
213 CGA TGA Arg Stop SM NCI-H1926 306 22 wt in COSMIC
245 GGC CGC Gly Arg SM NCI-H1930 20 2249 Mutation in COSMIC database
147 GTT GAT Val Asp DMU NCI-H1963 7 22 wt in COSMIC
214 CAT CGT His Arg DMU NCI-H1963 69 22 wt in COSMIC
220 TAT GAT Tyr Asp SM NCI-H2029 5 2249 Mutation in COSMIC database
248 CGG CAG Arg Gln SM NCI-H211 883 22 Single report
209 AGA TGA Arg Stop SM NCI-H2141 14 22 Single report
144 CAG TAG Gln Stop SM NCI-H2171 53 2249 Mutation in COSMIC database
157 GTC TTC Val Phe SM NCI-H2196 177 2249 Mutation in COSMIC database
134 TTT TTA Phe Leu SM NCI-H231 4 9 Single report
65 AGA TGA Arg Stop SM NCI-H2330 9 2249 Mutation in COSMIC database
277 TGT TTT Cys Phe SM NCI-H250 48 2249 Mutation in COSMIC database
236 TAC TGC Tyr Cys SM NCI-H345 75 2249 Mutation in COSMIC database
282 CGG GGG Arg Gly SM NCI-H510 48 22 wt in COSMIC
283 CGC CCC Arg Pro SM NCI-H64 35 2249 Mutation in COSMIC database
171 GAG TAG Glu Stop SM NCI-H69 25 47 Confirmed in three other publications
248 CGG CAG Arg Gln SM NCI-H719 883 2249 Mutation in COSMIC database
342 CGA TGA Arg Stop SM NCI-H774 74 22 Confirmed in another publication
242 TGC TCC Cys Ser SM NCI-H841 19 1382 Single report
242 TGC TCC Cys Ser SM NCI-H889 19 17 Confirmed in another publication
298 GAG TAG Glu Stop SM NCI-N417 71 106 Single report
298 GAG TAG Glu Stop SM RERF-LCMA 71 364 Confirmed in another publication
120 AAG TAG Lys Stop SM SBC-1 2 2249 Mutation in COSMIC database
248 CGG CTG Arg Leu SM SBC-5 124 364 Confirmed in another publication. wt in COSMIC
278 CCT CGT Pro Arg SM SCLC-21H 39 2249 Mutation in COSMIC database
85 CCT del1 Pro Fs. SM SK-LC-2 1 1976 Single report
259 GAC GTC Asp Val SM U-1690 21 2021 Single report
248 CGG CTG Arg Leu SM U-1906 124 2021 Single report

 

 

 
 
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