Cell lines database

p53 database

p53 mutations in cell lines

The hanbook of p53 mutation in cell lines

Cell lines with a controversial p53 status

The NCI 60 panel

Bladder cancer cell lines

Brain cancer cell lines

Breast cancer cell lines

Cervical carcinoma

Colorectal cancer cell lines

Esophageal cancer cell lines

Gastric cancer cell lines

Head and Neck cancer cell lines

Leukemia / Lymphoma cell lines

NSCLC cancer cell lines

Ovarian cancer cell lines

Pancreatic cancer cell lines

Sarcoma cell lines

SCLC cancer cell lines

Melanoma cell lines

Hepatocellular carcinoma

References

Brain tumours

Table I : cell lines with wt p53

* Cytoplasmic p53
** a recent publication describes an abberant splice in this cell line leading to the expression of a 369 aa protein that lack the NLS (Nakamura Y, Ozaki T, Niizuma H, Ohira M, Kamijo T, Nakagawara A (2007) Functional characterization of a new p53 mutant generated by homozygous deletion in a neuroblastoma cell line. Biochem Biophys Res Commun 354: 892-898.)

Table II : cell lines with p53 gene deletion or rearrangement

Table III : cell lines with p53 splice mutation
(exonic mutations that modify splice are listed in table IV)

No data available

Table IV: cell lines with p53 mutations (missense or frameshift)
More information is available in the handbook

Pos: Codon position (1 to 393);
WT: Normal base sequence of the codon in which the mutation occurred;
Mut Sequence of the mutated codon. If the mutation is a deletion or an insertion, it is indicated by "del" or "ins" followed by the number of deleted or inserted bases. The position in the codon is indicated by “a”, “b”, or “c” for the first, second or third base of the codon respectively. Example: "del66b" is a deletion of 66 bases including the second base of the codon; "ins4a" is an insertion of 4 bases occurring between the first and the second base of the codon. Label a, b, or c is omitted if the boundary of the deletion or insertion is unknown
AA: Wild type amino acid;
Mut: Mutant amino acid. Stop: nonsense mutation: Fs.: Frameshift mutation: InF: In-frame insertion or deletion;
Comp: complexity of the mutation: SM: Single mutational event in the tumor; DMU (Double Mutation Unknown): Two p53 mutations in the same tumor but their allelique distribution is unknown; DMD (Double Mutation Different allele): Two p53 mutations in the same tumor on two different p53 alleles; DMS (Double Mutation Same allele): Two p53 mutations in the same tumor on the same p53 allele: MM (Multiple Mutation): More than two p53 mutations in the same tumor;
NB: Number of tumors with this particular mutant in the database;
Ref: reference number;
Comments: information;

Table of references (available also in the handbook)