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Our Workp53 structureXenopus p53p53 in Lung cancerp53 in Breast cancerp53 antibodies in cancerp73 antibodies in cancerPublications of the lab
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Publications (2001-2008)2008Zander, C. S. & Soussi, T. (2008). Breast-cancer stromal cells with TP53 mutations. N Engl J Med, 358(15), 1635; author reply 1636. 2007 Soussi, T. (2007). p53 alterations in human cancer: more questions than answers. Oncogene, 26(15), 2145-2156. Download the pdf Soussi, T. & Wiman, K. G. (2007). Shaping genetic alterations in human cancer: the p53 mutation paradigm. Cancer Cell, 12(4), 303-312. Download the pdf Ren, Z. P., Olofsson, T., Qu, M., Hesselager, G., Soussi, T., Kalimo, H. et al. (2007). Molecular genetic analysis of p53 intratumoral heterogeneity in human astrocytic brain tumors. J Neuropathol Exp Neurol, 66(10), 944-954. Download the pdf 2006Soussi, T., Ishioka, C., Claustres, M. and Beroud, C. (2006) Locus-specific mutation databases: pitfalls and good practice based on the p53 experience. Nat Rev Cancer, 6, 83-90. Download the pdf Hamroun, D., Kato, S., Ishioka, C., Claustres, M., Beroud, C. and Soussi, T. (2006) The UMD TP53 database and website: update and revisions. Hum Mutat, 27, 14-20. Download the pdf Soussi, T., Asselain, B., Hamroun, D., Kato, S., Ishioka, C., Claustres, M. and Beroud, C. (2006) Meta-analysis of the p53 mutation database for mutant p53 biological activity reveals a methodologic bias in mutation detection. Clin Cancer Res, 12, 62-69. Download the pdf Iacopetta B, Russo A, Bazan V, Dardanoni G, Gebbia N, Soussi T, Kerr D, Elsaleh H, Soong R, Kandioler D, Janschek E, Kappel S, Lung M, Leung CS, Ko JM, Yuen S, Ho J, Leung SY, Crapez E, Duffour J, Ychou M, Leahy DT, O'donoghue DP, Agnese V, Cascio S, Di Fede G, Chieco-Bianchi L, Bertorelle R, Belluco C, Giaretti W, Castagnola P, Ricevuto E, Ficorella C, Bosari S, Arizzi CD, Miyaki M, Onda M, Kampman E, Diergaarde B, Royds J, Lothe RA, Diep CB, Meling GI, Ostrowski J, Trzeciak L, Guzinska-Ustymowicz K, Zalewski B, Capella GM, Moreno V, Peinado MA, Lonnroth C, Lundholm K, Sun XF, Jansson A, Bouzourene H, Hsieh LL, Tang R, Smith DR, Allen-Mersh TG, Khan ZA, Shorthouse AJ, Silverman ML, Kato S, Ishioka C (2006) Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study. Ann Oncol 17: 842-847. Download the pdf 2005Soussi, T. (2005). 25 Years of p53 Research. Wiman, K. & Hainaut, P. (eds.). Springer: pp 225-292. Download the pdf Soussi, T., Kato, S., Levy, P.P. and Ishioka, C. (2005) Reassessment of the TP53 mutation database in human disease by data mining with a library of TP53 missense mutations. Hum Mutat, 25, 6-17. Download the pdf Soussi, T. and Lozano, G. (2005) p53 mutation heterogeneity in cancer. Biochem Biophys Res Commun, 331, 834-842. Download the pdf Soussi, T. (2005) The p53 pathway and human cancer. Br J Surg, 92, 1331-1332. Russo, A., Bazan, V., Iacopetta, B., Kerr, D., Soussi, T. and Gebbia, N. (2005) The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: influence of tumor site, type of mutation, and adjuvant treatment. J Clin Oncol, 23, 7518-7528. Download the pdf Beroud, C., Hamroun, D., Collod-Beroud, G., Boileau, C., Soussi, T. and Claustres, M. (2005) UMD (Universal Mutation Database): 2005 update. Hum Mutat, 26, 184-191. Download the pdf 2004Favis, R., Huang, J., Gerry, N.P., Culliford, A., Paty, P., Soussi, T. and Barany, F. (2004) Harmonized microarray/mutation scanning analysis of TP53 mutations in undissected colorectal tumors. Hum Mutat, 24, 63-75. Download the pdf Fouquet, C., Antoine, M., Tisserand, P., Favis, R., Wislez, M., Commo, F., Rabbe, N., Carette, M.F., Milleron, B., Barany, F., Cadranel, J., Zalcman, G. and Soussi, T. (2004) Rapid and sensitive p53 alteration analysis in biopsies from lung cancer patients using a functional assay and a universal oligonucleotide array: a prospective study. Clin Cancer Res, 10, 3479-3489. Download the pdf Maillart, E., Brengel-Pesce, K., Capela, D., Roget, A., Livache, T., Canva, M., Levy, Y. and Soussi, T. (2004) Versatile analysis of multiple macromolecular interactions by SPR imaging: application to p53 and DNA interaction. Oncogene, 23, 5543-5550. Download the pdf Truong, K., Gibaud, A., Zalcman, G., Guilly, M.N., Antoine, M., Commo, F., Fouquet, C., Cadranel, J., Soussi, T., Dutrillaux, B. and Malfoy, B. (2004) Quantitative fish determination of chromosome 3 arm imbalances in lung tumors by automated image cytometry. Med Sci Monit, 10, BR426-432. Voeltzel T, Morel AP, Rostan MC, Ji J, Chiodino C, Ponchel F, Vigouroux J, de Fromentel CC, Soussi T and Ozturk M (2004) A new set of monoclonal antibodies directed to proline-rich and central regions of p53. Hybrid Hybridomics 23: 287-92. 2003Bensaad, K., Le Bras, M., Unsal, K., Strano, S., Blandino, G., Tominaga, O., Rouillard, D. and Soussi T (2003) Change of Conformation of the DNA-binding Domain of p53 Is the Only Key Element for Binding of and Interference with p73. J Biol Chem, 278, 10546-10555. Béroud, C. and Soussi T (2003) The UMD-p53 database: New mutations and analysis tools. Hum Mutat, 21, 176-181.Download the pdf Dendale, R., Vincent-Salomon, A., Mouret-Fourme, E., Savignoni, A., Medioni, J., Campana, F., Vilcoq, J.R., de la Rochefordiere, A., Soussi T., Asselain, B., de Cremoux, P. and Fourquet, A. (2003) Medullary breast carcinoma: prognostic implications of p53 expression. Int J Biol Markers, 18, 99-105. Holmila, R., Fouquet, C., Cadranel, J., Zalcman, G. and Soussi T. (2003) Splice mutations in the p53 gene: case report and review of the literature. Hum Mutat, 21, 101-102. Download the pdf Le Bras, M., Bensaad, K. and Soussi T. (2003) Data mining the p53 pathway in the Fugu genome: evidence for strong conservation of the apoptotic pathway. Oncogene, 22, 5082-5090.Download the pdf Sangrajrang, S., Arpornwirat, W., Cheirsilpa, A., Thisuphakorn, P., Kalalak, A., Sornprom, A. and Soussi T (2003) Serum p53 antibodies in correlation to other biological parameters of breast cancer. Cancer Detect Prev, 27, 182-186.Download the pdf Sangrajrang, S., Sornprom, A., Chernrungroj, G. and Soussi T. (2003) Serum p53 antibodies in patients with lung cancer: correlation with clinicopathologic features and smoking. Lung Cancer, 39, 297-301.Download the pdf Soussi T. (2003) Focus on the p53 gene and cancer: advances in TP53 mutation research. Hum Mutat, 21, 173-175.Download the pdf Soussi T (2003) p53 mutations and resistance to chemotherapy: A stab in the back for p73. Cancer Cell, 3, 303-305.Download the pdf Soussi T (2003) [p53 mutations and resistance to chemotherapy: a stab in the back for p73 ?]. Bull Cancer, 90, 383-386. Soussi T and Béroud, C. (2003) Significance of TP53 mutations in human cancer: A critical analysis of mutations at CpG dinucleotides. Hum Mutat, 21, 192-200.Download the pdf Tisserand, P., Fouquet, C., Barrois, M., Gallou, C., Dendale, R., Stoppa-Lyonnet, D., Sastre-Garau, X., Fourquet, A. and Soussi, T. (2003) Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors. Cancer Biol Ther, 2, 559-563. Download the pdf Tisserand, P., Fouquet, C., Marck, V., Mallard, C., Fabre, M., Vielh, P. and Soussi T (2003) ThinPrep-processed fine-needle samples of breast are effective material for RNA- and DNA-based molecular diagnosis: application to p53 mutation analysis. Cancer, 99, 223-232 Download the pdf 2002Duriez, C., Falette, N., Audoynaud, C., Moyret-Lalle, C., Bensaad, K., Courtois, S., Wang, Q., Soussi T. and Puisieux, A. (2002) The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene. Gene, 282, 207-214. Download the pdf Huang, J., Kirk, B., Favis, R., Soussi T., Paty, P., Cao, W. and Barany, F. (2002) An endonuclease/ligase based mutation scanning method especially suited for analysis of neoplastic tissue. Oncogene, 21, 1909-1921. Download the pdf Janssen, K.P., el-Marjou, F., Pinto, D., Sastre, X., Rouillard, D., Fouquet, C., Soussi T., Louvard, D. and Robine, S. (2002) Targeted expression of oncogenic K-ras in intestinal epithelium causes spontaneous tumorigenesis in mice. Gastroenterology, 123, 492-504.Download the pdf Le Bras, M., Delattre, V., Bensaad, K., Blandino, G. and Soussi T (2002) Monoclonal antibodies raised against Xenopus p53 interact with human p73. Oncogene, 21, 1304-1308. Download the pdf Soussi T. (2002) Immunochemistry and genotype analysis of tumors. Second part: What future for the molecular diagnosis of tumors? Ann Pathol, 22, 113-120. Vielh P, Klijanienko J, Cosyn S, Padoy E, Couturier J, Soussi T and M, F. (2002) Use of ThinPrep preparates for implementation of other techniques: immunocytochemistry, flow cytometry and molecular biology. Ann Pathol, 22, S63-S 2001Bensaad, K., Rouillard, D. and Soussi T. (2001) Regulation of the cell cycle by p53 after DNA damage in an amphibian cell line. Oncogene, 20, 3766-3775.Download the pdf Jassem, E., Bigda, J., Dziadziuszko, R., Schlichtholz, B., Le Roux, D., Grodzki, T., Rzyman, W., Konopa, K., Poberezna, M., Dobrzanska, Z., Skokowski, J.,Soussi T and Jassem, J. (2001) Serum p53 antibodies in small cell lung cancer: the lack of prognostic relevance. Lung Cancer, 31, 17-23. Download the pdf Soussi T. and Béroud, C. (2001) Assessing TP53 status in human tumours to evaluate clinical outcome. Nat. Rev. Cancer, 1, 233-240 .Download the pdf Tominaga, O., Unsal, K., Zalcman, G. and Soussi T. (2001) Detection of p73 antibodies in patients with various types of cancer: immunological characterization. Br J Cancer, 84, 57-63.Download the pdf Yolcu, E., Sayan, B.S., Yagci, T., Cetin-Atalay, R., Soussi T., Yurdusev, N. and Ozturk, M. (2001) A monoclonal antibody against DNA binding helix of p53 protein. Oncogene, 20, 1398-1401.Download the pdf
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