The p53 Mutation Handbook is a compilation of multiple
analyses performed using information from the UMD p53 Mutation database
Which
release of the UMD TP53 database was used for these analyses?
Except when otherwise specified, the curated version
of the 2008_R2 release of the UMD p53 mutation database was used.
What
is the difference between the curated and uncurated version of the p53 database?
The curated version of the UMD TP53 database has been
purged from artefactual data known to affect p53 mutation analysis. More
information can be found on our website (http://p53.free.fr/Database/p53_database.html) or in our recent publication (Soussi, T., Asselain, B., Hamroun, D., Kato, S., Ishioka,
C., Claustres, M. and Beroud, C. (2006) Meta-analysis of the p53 mutation
database for mutant p53 biological activity reveals a methodological bias in
mutation detection. Clin Cancer Res, 12, 62-69.)
How
were the various analyses performed?
Using novel software, the entire UMD TP53 mutation
database was automatically analyzed resulting in the p53 Mutation Handbook as
an output.
What
type of information can be found in the p53 Mutation HandBook?
The p53 Mutation Handbook presents an analysis of TP53
mutation distribution and mutational events in the most frequent human cancers.
It also contains helpful reference pages about the human
p53 sequence and how each codon of the protein is mutated in human cancer.
What
is the reference of the p53 Mutation HandBook?
L. Hjortsberg, J.M. Rubio-Nevado, D. Hamroun, C.
Béroud, M. Claustre and T Soussi,. The p53 Mutation handbook 2.0, available
online; http://p53.free.fr
What
is the audience for this handBook?
Every scientist interested in p53 mutations or more
globally in mutation analysis in human cancer.
What
if I need a specific analysis which is not included in this p53 Mutation
handbook?
Just send us an email (p53@free.fr) and, if your request is feasible, the analysis will
be performed and added to the handbook.
You can also make suggestions via our Forum
(http://p53.free.fr/Forum)
What
is the future of the p53 Mutation HandBook?
More analyses and novel information will be added to
the next version. Stay tuned!
Version
History
2.0 October 2008
Update with the 2008 release of the UMD p53 database
Add new analysis
Add strategy of analysis for the most frequent cancer
1.1 March 2007
Modification of the CpG mutation analysis page 68 and
69
1.0
Release of the p53 Mutation HandBook, February 2007
