p53 database

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Database curation

MUT-MAT 2: p53 mutation prediction

p53 mutation in cell lines
(new)

p53 mutation and cancers: an extensive analysis of p53 mutation in every cancer

The p53 Mutation Handbook

p53 mutation distribution

p53 mutation in breast cancer: about apples, oranges and unusual p53 mutations:
a response to Patoc et al.

MUT-TP53: A novel versatile matrix for statistical analysis of TP53 mutations in human cancer

MUT-TP53 2.0, an accurate and powerful tool that will automatically handle p53 mutations and generate tables ready for publication that will lower the risk of typographical errors.

Analysis of the literature reporting TP53 mutations shows that 8% of reports display typographical errors, with a marked increase over recent years. These errors are sometimes isolated, but, in some cases, they concern several or even all mutations described in a single article.

Furthermore, some papers report an unusual profile of p53 mutations, the accuracy of which is difficult to assess. In order to manage these problems, we have developed MUT-TP53, an accurate and powerful tool that will automatically process p53 mutations and generate tables ready for publication that will decrease the risk of typographical errors. Furthermore, using functional and statistical information derived from the UMD p53 database, this matrix can be used to assess the biological activity and likelihood of each TP53 mutant

A second version (July 2010) of MUT_MAT is now available (Soussi et al., 2010 in press)

	MUT_MAT 1.0 (2006)	MUT_MAT 2.0 (2010)
Handle p53 sequence to prevent codon miss identification	Yes	Yes
Use genetic code to handle mutations	Yes	Yes
Display functional data for each mutant p53	Yes	Yes
Generate a p53 mutation tables ready for publication	Yes	Yes
Identify every TP53 natural polymorphisms	No	Yes
Cover every single, double or triple nucleotide substitution at each codon of the p53 gene	No	Yes
Include information for TP53 mutant with unusual behavior (T125T, R337H, etc)	No	Yes
Include information for splicing mutation	No	Yes
Compare the profile of p53 inactivation with other publications	No	Yes
Statistical analysis of p53 loss of function	No	Yes

Download
MUT-TP53 2.0
The documentation
MUT-TP53 2.0 with data
The manuscript

Output example: Ten mutant p53 showing the various features of MUT-MAT V2.0 were analyzed. Mutants in sample 1 (p.R175H), sample 2 (p.K132E), sample 5 (p.T125T), sample 6 (p.S260S), sample 7 (p.R337H) and sample 8 (p.N200P) have been described in the tumor database. In sample 3, the spreadsheet identifies the exonic SNP in exon 4 at codon 72. In sample 4, the matrix identifies a typographical error, as wt and mutant codon are identical. Mutants in sample 9 and 10 correspond to the substitution of two non-contiguous residues or 3 residues. These mutational events are very unusual in the p53 gene and are flagged accordingly. See text for more information. Nucleotide numbering reflects cDNA numbering with +1 corresponding to the A of the ATG translation initiation codon in the reference sequence (GDB: 120445).

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The UMD p53 database is protected by the European Union Council Directive N° 96/9/EC, OJ (L77) 20 (1996). Extracting, copying or reuse of data from databases without permission are covered by this directive