Created in 1994, this web site is a reference for all scientist working on p53 or in cancer research in general. I had the privilege to perform my Post Doc in the laboratory of Dr. P. May and work with Dr. M. Kress, who signed one of the first publication on p53 in 1979. As I always recount, I choose to carry on my work on p53 because it was a very quiet field and the teaching duty of a young assistant professor in France is 192 hours of lectures per year. I still don't know whether I made a mistake or not.
Nevertheless, the p53 field has expanded and in this web site, I have gathered more than 20 years of information including the never-ending expansion of the UMD p53 mutation database, the description of all p53 monoclonal antibodies, the phylogenetic analysis of p53 and other useful data. This site is also your site and if you feel that some information are missing or could be wrong, please let us know.
November 2008
p53 database
The UMD p53 mutation database and a section dedicated to the analysis of p53 mutations in human cancer. The 2008_R2 release of the UMD_TP53 Mutation database (2384 references, 28 513 mutations) is now available (October 2008).
The UMD_TP53 is the only available database which have been curated by removing publications associated with artefactual data. More Information
The p53 Mutation HandBook 2.0 that summarizes everything on p53 mutation is now available for download ->Link
New: p53 status in human cancer cell lines
This novel section was developed in 2008. we found discrepancies in the p53 status for 23% (88/384) of cell lines, for which the p53 status was established independently in two laboratories. This new section describes the p53 status in the majority of cell lines with a special section devoted to cell lines with controversial p53 status. More Information
Our Work
Summary of our studies and projects
p53 Information
p53 Knowledge Center with a huge amount of novel information on p53
Link
Useful links related to p53 and cancer
The Forum for discussion/ exchange has been opened. It is still tentative. The goal of this forum is to promote exchange between members in the scientific community: Discussions about recent publications, new ideas and models or any topic related to the p53 field.
The next p53 meeting 2010: Philadelphia
A last point: until the last version of this web site, I did not mention any copyright or any legal notice concerning the content of this site. Unfortunately, I have noticed that several sections of this site including the entire database have been used in other websites without any authorization. I would like to mention that this site is copyrighted and that the UMD p53 database is protected by the European Union Council Directive N° 96/9/EC, OJ (L77) 20 (1996). Extracting, copying or reuse of data from databases without permission are covered by this directive.
Professor Thierry Soussi
Everything you always wanted to know about p53 but were afraid to ask ....
April 2005
Click the cover for access
A special issue of Human mutation
Focus on p53 and Cancer.
T. Soussi and C. Béroud: Guest Editors
All articles are free online
Click the cover for access
Our p53 web site has been recently awarded as one of the best educational resources on the Web by StudySphere
